Numaga T, Wakamori M, Mori Y
Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, 615-8510 Kyoto, Japan.
Handb Exp Pharmacol. 2007(179):143-51. doi: 10.1007/978-3-540-34891-7_8.
Canonical transient receptor potential7 (TRPC7) is the seventh identified member of the mammalian TRPC channel family, comprising nonselective cation channels activated through the phospholipase C (PLC) signaling pathway. TRPC7 is directly activated by diacylglycerol (DAG), one of the PLC products, having high sequence homologywith TRPC3 and TRPC6, which are also activated by DAG. TRPC7 shows unique properties of activation, such as constitutive activity and susceptibility to negative regulation by extracellular Ca2+. Although the physiological importance of TRPC7 in the native environment remains elusive, TRPC7 would play important roles in Ca2+ signaling pathway through these characteristic features.
典型瞬时受体电位7（TRPC7）是哺乳动物TRPC通道家族中被鉴定出的第七个成员，该家族由通过磷脂酶C（PLC）信号通路激活的非选择性阳离子通道组成。TRPC7由PLC的产物之一二酰基甘油（DAG）直接激活，它与同样由DAG激活的TRPC3和TRPC6具有高度的序列同源性。TRPC7表现出独特的激活特性，如组成性活性以及对细胞外Ca2+负调控的敏感性。尽管TRPC7在天然环境中的生理重要性仍不清楚，但通过这些特征，TRPC7可能在Ca2+信号通路中发挥重要作用。
