Azizi Najmedin, Aryanasab Fezzeh, Saidi Mohammad R
Department of Chemistry, Sharif University of Technology, P. O. Box 11465-9516, Tehran 11365, Iran.
Org Lett. 2006 Nov 9;8(23):5275-7. doi: 10.1021/ol0620141.
[Structure: see text] A highly efficient and simple synthesis of dithiocarbamates is possible based on the one-pot reaction of amines, CS2, and alkyl halides without using a catalyst under solvent-free conditions. The mild reaction conditions, high yields, and broad scope of the reaction illustrate the good synthetic utility of this method. The reaction is a highly atom-economic process for production of S-alkyl thiocarbamates and successfully can be used in high quantities in the pharmaceutical or agrochemical industries.
[结构：见正文] 在无溶剂条件下，无需使用催化剂，基于胺、二硫化碳和卤代烃的一锅法反应，可实现二硫代氨基甲酸盐的高效简便合成。温和的反应条件、高收率以及广泛的反应范围表明了该方法良好的合成实用性。该反应是生产S-烷基硫代氨基甲酸盐的高度原子经济的过程，并且成功地可大量用于制药或农用化学品工业。
