Míguez J, Martín F, Míguez I, Aldegunde M
Departamento de Fisiología Animal, Facultad de Biología, Universidad de Santiago de Compostela, Galicia, Spain.
J Pineal Res. 1991 Sep;11(2):75-9. doi: 10.1111/j.1600-079x.1991.tb00459.x.
In the present study, the effects of long-term pinealectomy on tryptophan, 5-hydroxytryptamine (5-HT or serotonin), 5-hydroxy-3-indoleacetic acid (5-HIAA), and tryptophan hydroxylase and monoamine oxidase activities were studied in preoptic area-anterior hypothalamus (POA-AH) and in the medial and posterior hypothalamus of the rat. After pinealectomy, 5-HT levels decreased significantly in medial hypothalamus but increased in the POA-AH. The levels of 5-HIAA decreased significantly in the POA-AH and medial hypothalamus. Tryptophan levels remained unchanged while tryptophan hydroxylase activity diminished significantly in POA-AH and medial hypothalamus. Monoamine oxidase activity remained unchanged in the hypothalamic regions. These results suggest that pinealectomy induces differential inhibitory actions on the serotoninergic terminal regions, mainly in anterior and medial hypothalamic areas.
在本研究中，我们研究了长期松果体切除对大鼠视前区-下丘脑前部（POA-AH）以及下丘脑内侧和后部中色氨酸、5-羟色胺（5-HT或血清素）、5-羟-3-吲哚乙酸（5-HIAA）、色氨酸羟化酶和单胺氧化酶活性的影响。松果体切除后，下丘脑内侧的5-HT水平显著降低，但在POA-AH中升高。POA-AH和下丘脑内侧的5-HIAA水平显著降低。色氨酸水平保持不变，而POA-AH和下丘脑内侧的色氨酸羟化酶活性显著降低。下丘脑区域的单胺氧化酶活性保持不变。这些结果表明，松果体切除对5-羟色胺能终末区域产生差异性抑制作用，主要作用于下丘脑前部和内侧区域。
