Higgins Stephen T, Heil Sarah H, Dantona Robert, Donham Robert, Matthews Martha, Badger Gary J
Department of Psychiatry, University of Vermont, Burlington, VT 05401, USA.
Addiction. 2007 Feb;102(2):271-81. doi: 10.1111/j.1360-0443.2006.01664.x.
This study examined whether increasing the amount of abstinence achieved during outpatient treatment for cocaine dependence is an effective method for increasing longer-term cocaine abstinence.
A two-condition, parallel groups, randomized controlled trial was conducted.
The trial was conducted in a university-based research clinic.
A total of 100 cocaine-dependent outpatients participated in the trial.
Participants were assigned randomly to receive treatment based on the community reinforcement approach (CRA) plus voucher-based incentives set at a relatively high monetary value (maximal value = $1995/12 weeks) or CRA with vouchers set at a relatively low monetary value (maximal value = $499/12 weeks). Vouchers were earned contingent on cocaine-negative urinalysis results during the initial 12 weeks of the 24-week outpatient treatment.
Outcomes were evaluated using urine-toxicology testing, questionnaires and other self-report instruments.
Increasing voucher value increased the duration of continuous cocaine abstinence achieved during the 24-week treatment period. Point-prevalence cocaine abstinence assessed every 3 months throughout an 18-month follow-up period was greater in the high- than low-value voucher conditions. The duration of abstinence achieved during treatment predicted abstinence during follow-up, although that relationship weakened over time.
Increasing the value of abstinence-contingent incentives during the initial weeks of treatment appears to represent an effective method for increasing during-treatment and longer-term cocaine abstinence, but the positive association of during-treatment abstinence with longer-term outcome dissipates with time.
本研究探讨在门诊治疗可卡因依赖期间增加戒断量是否是增加长期可卡因戒断的有效方法。
进行了一项双条件、平行组、随机对照试验。
试验在一家大学研究诊所进行。
共有100名可卡因依赖门诊患者参与了试验。
参与者被随机分配接受基于社区强化方法(CRA)加设定相对高货币价值(最高价值 = 1995美元/12周)的代金券激励措施的治疗,或接受设定相对低货币价值(最高价值 = 499美元/12周)的代金券的CRA治疗。在为期24周的门诊治疗的最初12周内,如果尿液分析结果为可卡因阴性,则可获得代金券。
使用尿液毒理学检测、问卷和其他自我报告工具评估结果。
增加代金券价值可增加24周治疗期间实现持续可卡因戒断的持续时间。在18个月的随访期内,每3个月评估一次的点患病率可卡因戒断情况,高价值代金券组比低价值代金券组更高。治疗期间实现的戒断持续时间可预测随访期间的戒断情况,尽管这种关系会随着时间减弱。
在治疗的最初几周增加基于戒断的激励措施的价值似乎是增加治疗期间及长期可卡因戒断的有效方法,但治疗期间的戒断与长期结果之间的正相关关系会随着时间消失。