Hormigo Adília, Gutin Philip H, Rafii Shahin
Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Cancer Cell. 2007 Jan;11(1):6-8. doi: 10.1016/j.ccr.2006.12.008.
Clinical assessment of the response to antiangiogenic therapy has been cumbersome. A study in this issue of Cancer Cell demonstrates that a combination of magnetic resonance imaging (MRI) for quantification of normalized vessels with measurements of circulating levels of proangiogenic factors, including FGF2, SDF1, and viable circulating endothelial cells, provides an effective means to evaluate the response of recurrent glioblastoma to a prototypical pan-VEGF receptor tyrosine kinase inhibitor, AZD2171.
对抗血管生成疗法反应的临床评估一直很繁琐。本期《癌细胞》杂志上的一项研究表明,将用于量化正常化血管的磁共振成像(MRI)与对促血管生成因子(包括FGF2、SDF1和存活的循环内皮细胞)循环水平的测量相结合,提供了一种有效的方法来评估复发性胶质母细胞瘤对典型的泛VEGF受体酪氨酸激酶抑制剂AZD2171的反应。