Division of Neurosurgery, Duke University Medical Center, Box 3807, Durham, NC 27710, USA.
Toxins (Basel). 2011 Mar;3(3):191-200. doi: 10.3390/toxins3030191. Epub 2011 Mar 15.
Determining radiographic progression in primary malignant brain tumors has posed a significant challenge to the neuroncology community. Glioblastoma multiforme (GBM, WHO Grade IV) through its inherent heterogeneous enhancement, growth patterns, and irregular nature has been difficult to assess for progression. Our ability to detect tumor progression radiographically remains inadequate. Despite the advanced imaging techniques, detecting tumor progression continues to be a clinical challenge. Here we review the different criteria used to detect tumor progression, and highlight the inherent challenges with detection of progression.
原发性脑恶性肿瘤的放射学进展一直是神经肿瘤学界面临的重大挑战。多形性胶质母细胞瘤（GBM，IV 级）因其固有的异质性增强、生长模式和不规则性而难以评估进展。我们在放射学上检测肿瘤进展的能力仍然不足。尽管有先进的成像技术，但检测肿瘤进展仍然是一个临床挑战。在这里，我们回顾了用于检测肿瘤进展的不同标准，并强调了检测进展所固有的挑战。
