Kulminski A, Yashin A, Arbeev K, Akushevich I, Ukraintseva S, Land K, Manton K
Center for Demographic Studies, Duke University, 2117 Campus Drive, Box 90408, Durham, NC 27708, United States.
Mech Ageing Dev. 2007 Mar;128(3):250-8. doi: 10.1016/j.mad.2006.12.004. Epub 2006 Dec 20.
We employ an approach based on the elaborated frailty index (FI), which is capable of taking into account variables with mild effect on the aging, health and survival outcomes, and investigate the connections between the FI, chronological age and the aging-associated outcomes in the elderly.
Cross-sectional analysis of pooled data from the National Long Term Care Survey (NLTCS) assessing health and functioning of the U.S. elderly in 1982, 1984, 1989, 1994, and 1999.
Distributions of frequency, residual life span, mortality rate, and relative risk of death are remarkably similar over age and FI. Coefficients of correlation between FI and age are low both for males (0.127, p<.01) and females (0.221, p<.01). The FI-specific age patterns show deceleration at advanced ages. The FI can provide order of magnitude better resolution in estimating mean remaining life span compared to age. Males have smaller FI than females while males' mortality risks are higher. For short-time horizons, the FI and age are largely independently associated with mortality risks.
The FI: (i) can be considered as an adequate sex-specific indicator of the aging-associated processes in the elderly, (ii) can characterize these processes independently of age, and (iii) is a better characteristic of the aging phenotype than chronological age.
我们采用一种基于精细衰弱指数（FI）的方法，该方法能够考虑到对衰老、健康和生存结果有轻微影响的变量，并研究FI、实足年龄与老年人衰老相关结果之间的联系。
对来自国家长期护理调查（NLTCS）的汇总数据进行横断面分析，该调查评估了1982年、1984年、1989年、1994年和1999年美国老年人的健康和功能状况。
频率、剩余寿命、死亡率和死亡相对风险的分布在年龄和FI上非常相似。男性（0.127，p<0.01）和女性（0.221，p<0.01）的FI与年龄之间的相关系数都很低。FI特定的年龄模式在高龄时显示出减速。与年龄相比，FI在估计平均剩余寿命方面能提供更好的数量级分辨率。男性的FI比女性小，而男性的死亡风险更高。在短时间范围内，FI和年龄在很大程度上与死亡风险独立相关。
FI：（i）可被视为老年人衰老相关过程的一个适当的性别特异性指标，（ii）可以独立于年龄来表征这些过程，并且（iii）比实足年龄更能体现衰老表型。
