Quinn Claire, Ryan Edward, Claessens E Anne, Greenblatt Ellen, Hawrylyshyn Peter, Cruickshank Barbara, Hannam Thomas, Dunk Caroline, Casper Robert F
Division of Reproductive Sciences, Samuel Lunenfeld Research Institute, and the Fran and Lawrence Bloomberg Department of Obstetrics and Gynecology, Mount Sinai Hospital, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
Fertil Steril. 2007 May;87(5):1015-21. doi: 10.1016/j.fertnstert.2006.08.101. Epub 2007 Jan 16.
To assess pinopode formation in human endometrium during the luteal phase of the menstrual cycle and in the first trimester of pregnancy.
Prospective clinical study.
Outpatient infertility clinics and outpatient family planning clinic.
PATIENT(S): Thirty-two regularly cycling infertile women, 15 regularly cycling fertile women, 9 women receiving elective termination of pregnancy, and 1 woman receiving GnRH agonist and hormone therapy addback.
INTERVENTION(S): Endometrial tissue was collected by suction pipelle and examined by scanning electron microscopy for pinopode formation.
MAIN OUTCOME MEASURE(S): Endometrial tissue was scored (0, 1, 2, 3, or 4) depending on the percentage of the surface covered in pinopodes (from 0% to >20% of 100 fields).
RESULT(S): Pinopodes were present throughout the luteal phase of the menstrual cycle, up to the 11th week of pregnancy, and in the endometrium of the woman on GnRH agonist and hormone therapy.
CONCLUSION(S): Pinopodes can be detected in the progesterone-exposed endometrium for an extended period of time, in contradistinction to the perception that they are markers for the implantation window in the human endometrium.
评估月经周期黄体期及妊娠早期人子宫内膜中胞饮突的形成情况。
前瞻性临床研究。
门诊不孕不育诊所及门诊计划生育诊所。
32名月经周期规律的不孕女性、15名月经周期规律的可育女性、9名接受选择性终止妊娠的女性以及1名接受促性腺激素释放激素（GnRH）激动剂及激素补充治疗的女性。
通过吸管吸取收集子宫内膜组织，采用扫描电子显微镜检查胞饮突的形成情况。
根据胞饮突覆盖的表面积百分比（100个视野中从0%至>20%）对子宫内膜组织进行评分（0、1、2、3或4分）。
在月经周期的整个黄体期、直至妊娠11周以及接受GnRH激动剂及激素治疗女性的子宫内膜中均存在胞饮突。
与胞饮突是人类子宫内膜着床窗标志物的观点相反，在暴露于孕酮的子宫内膜中可在较长时间内检测到胞饮突。
