Rana S, Gallo A, Srivastava R S, Misra R D K
Center for Structural and Functional Materials, University of Louisiana at Lafayette, PO Box 44130, Lafayette, LA 70504-4130, USA.
Acta Biomater. 2007 Mar;3(2):233-42. doi: 10.1016/j.actbio.2006.10.006. Epub 2007 Jan 16.
Superparamagnetic nickel ferrite nanoparticles functionalized with polyvinyl alcohol, polyethylene oxide and polymethacrylic acid (PMAA) polymers and subsequently conjugated with doxorubicin anti-cancer drug are studied for their use as a magnetic carrier for drug delivery. Fourier transform infrared spectroscopy enabled examination of the ability of the nanoparticles to be functionalized with polymers and conjugated with doxorubicin drug. The functionalized polymer-coated nanocrystalline nickel ferrites retain the magnetic characteristics of non-functionalized nanocrystalline nickel ferrites (superparamagnetism, absence of hysteresis, remanence and coercivity at room temperature), encouraging their application as a magnetic carrier for drug delivery. The PMAA-coated nanoferrites are demonstrated as being a potentially superior magnetically targeted drug carrier based on FTIR results and drug release kinetics in the absence and presence of an external magnetic field.
研究了用聚乙烯醇、聚环氧乙烷和聚甲基丙烯酸（PMAA）聚合物功能化并随后与阿霉素抗癌药物共轭的超顺磁性镍铁氧体纳米颗粒作为药物递送磁性载体的用途。傅里叶变换红外光谱能够检测纳米颗粒被聚合物功能化以及与阿霉素药物共轭的能力。功能化聚合物包覆的纳米晶镍铁氧体保留了未功能化纳米晶镍铁氧体的磁性特征（超顺磁性，室温下无磁滞、剩磁和矫顽力），这促使它们作为药物递送磁性载体得到应用。基于傅里叶变换红外光谱结果以及在有无外部磁场情况下的药物释放动力学，证明PMAA包覆的纳米铁氧体是一种潜在的优质磁靶向药物载体。
