Gilbert David D, Bond Brent
Wake Forest University Eye Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1033, USA.
J Glaucoma. 2007 Jan;16(1):62-7. doi: 10.1097/IJG.0b013e31802b3944.
To design an apparatus for in vitro quantification of effects of modifications to nonvalved tube shunts, and to compare the effects of these modifications done to prevent early postoperative hypotony.
A testing apparatus was designed and constructed to measure intraluminal pressure (ILP) during constant infusion of balanced salt solution at 2 microL/min through Baerveldt tube shunts mounted on cadaver eyes. Three different modifications were performed and 3 shunts were used for each modification. The modifications were partial tube occlusion with a 3-0 Supramid suture, tube perforation with a 27-gauge needle on an occluded tube, and a 1.2 mm longitudinal venting slit on an occluded tube.
The final steady state ILP for the 3-0 Supramid partially occluded tube ranged between 1.6 and 2.8 mm Hg over 3 trials with an average final steady state ILP of 2.0 mm Hg. The 27-gauge needle perforation produced ILPs of 4.6 to 8.2 mm Hg over 3 trials with an average final steady state pressure of 5.9 mm Hg. The 1.2 mm longitudinal venting slit produced an ILP range of 12.6 to 17.3 mm Hg over 3 trials with an average final steady state ILP of 14.8 mm Hg. The differences in final steady state ILP between the 3 modification techniques were statistically significant (P=0.00036).
The 3-0 Supramid occlusion and the 27-gauge perforation techniques produced hypotony, whereas the 1.2 mm longitudinal venting slit produced acceptable pressures in vitro.
设计一种用于体外定量评估非瓣膜性管分流术改良效果的装置,并比较这些改良措施预防术后早期低眼压的效果。
设计并构建了一种测试装置,用于在以2微升/分钟的速度通过安装在尸体眼睛上的Baerveldt管分流器持续输注平衡盐溶液期间测量管腔内压力(ILP)。进行了三种不同的改良,每种改良使用3个分流器。改良措施分别为用3-0 Supramid缝线部分阻塞管腔、用27号针头在阻塞管上穿孔以及在阻塞管上设置1.2毫米的纵向排气狭缝。
在3次试验中,3-0 Supramid部分阻塞管的最终稳态ILP在1.6至2.8毫米汞柱之间,平均最终稳态ILP为2.0毫米汞柱。27号针头穿孔在3次试验中产生的ILP为4.6至8.2毫米汞柱,平均最终稳态压力为5.9毫米汞柱。1.2毫米纵向排气狭缝在3次试验中产生的ILP范围为12.6至17.3毫米汞柱,平均最终稳态ILP为14.8毫米汞柱。三种改良技术在最终稳态ILP上的差异具有统计学意义(P = 0.00036)。
3-0 Supramid阻塞和27号穿孔技术导致低眼压,而1.2毫米纵向排气狭缝在体外产生了可接受的压力。