Côté M, Matias I, Lemieux I, Petrosino S, Alméras N, Després J-P, Di Marzo V
Hôpital Laval Research Centre, Québec, Canada.
Int J Obes (Lond). 2007 Apr;31(4):692-9. doi: 10.1038/sj.ijo.0803539. Epub 2007 Jan 16.
The link between excess intra-abdominal adiposity (IAA) and metabolic complications leading to type 2 diabetes and cardiovascular disease is well recognized. Blockade of endocannabinoid action at cannabinoid CB(1) receptors was shown to reduce these complications. Here, we investigated the relationship between IAA, circulating endocannabinoid levels and markers of cardiometabolic risk in male obese subjects.
DESIGN, SUBJECTS AND MEASUREMENTS: Fasting plasma levels of the endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), were measured by liquid chromatography-mass spectrometry in a study sample of 62 untreated asymptomatic men with body mass index (BMI) from 18.7 to 35.2 kg/m(2).
Plasma 2-AG, but not AEA, levels correlated positively with BMI, waist girth, IAA measured by computed tomography, and fasting plasma triglyceride and insulin levels, and negatively with high-density lipoprotein cholesterol and adiponectin levels. Obese men with similar BMI values (> or =30 kg/m(2)) but who markedly differed in their amount of IAA (< vs > or = 130 cm(2), n=17) exhibited higher 2-AG levels in the presence of high IAA. No difference in 2-AG concentrations was observed between obese men with low levels of IAA vs nonobese controls.
These results provide evidence for a relationship in men between a key endocannabinoid, 2-AG, and cardiometabolic risk factors, including IAA.
腹内脂肪过多（IAA）与导致2型糖尿病和心血管疾病的代谢并发症之间的联系已得到充分认识。研究表明，阻断大麻素CB(1)受体处的内源性大麻素作用可减少这些并发症。在此，我们研究了男性肥胖受试者中IAA、循环内源性大麻素水平与心脏代谢风险标志物之间的关系。
设计、受试者与测量方法：通过液相色谱-质谱法测量了62名未经治疗的无症状男性研究样本的空腹血浆内源性大麻素水平，这些男性的体重指数（BMI）在18.7至35.2 kg/m(2)之间，内源性大麻素包括花生四烯乙醇胺（AEA）和2-花生四烯酸甘油酯（2-AG）。
血浆2-AG水平而非AEA水平与BMI、腰围、通过计算机断层扫描测量的IAA、空腹血浆甘油三酯和胰岛素水平呈正相关，与高密度脂蛋白胆固醇和脂联素水平呈负相关。BMI值相似（≥30 kg/m(2)）但IAA量显著不同（< vs ≥130 cm(2)，n = 17）的肥胖男性，在IAA水平高时2-AG水平更高。IAA水平低的肥胖男性与非肥胖对照组之间未观察到2-AG浓度差异。
这些结果为男性体内关键内源性大麻素2-AG与包括IAA在内的心脏代谢风险因素之间的关系提供了证据。
