Service de Chirurgie Maxillofaciale, Centre Hospitalier Universitaire de Nantes, Nantes, France.
PLoS One. 2007 Jan 17;2(1):e150. doi: 10.1371/journal.pone.0000150.
Baló's concentric sclerosis is a rare atypical form of multiple sclerosis characterized by striking concentric demyelination patterns. We propose a robust mathematical model for Baló's sclerosis, sharing common molecular and cellular mechanisms with multiple sclerosis. A reconsideration of the analogies between Baló's sclerosis and the Liesegang periodic precipitation phenomenon led us to propose a chemotactic cellular model for this disease. Rings of demyelination appear as a result of self-organization processes, and closely mimic Baló lesions. According to our results, homogeneous and concentric demyelinations may be two different macroscopic outcomes of a single fundamental immune disorder. Furthermore, in chemotactic models, cellular aggressivity appears to play a central role in pattern formation.
巴洛氏同心圆硬化症是一种罕见的多发性硬化症非典型形式，其特征是明显的同心圆脱髓鞘模式。我们提出了一个用于巴洛氏硬化症的强大数学模型，该模型与多发性硬化症具有共同的分子和细胞机制。重新考虑巴洛氏硬化症与李息格恩周期性沉淀现象之间的相似性，促使我们提出了这种疾病的趋化细胞模型。脱髓鞘环的出现是自组织过程的结果，与巴洛氏病变非常相似。根据我们的结果，均匀的和同心的脱髓鞘可能是单一基本免疫紊乱的两种不同宏观结果。此外，在趋化模型中，细胞侵袭性似乎在模式形成中起着核心作用。
