Karbowska J, Kochan Z
Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland.
J Physiol Pharmacol. 2006 Nov;57 Suppl 6:103-13.
Adiponectin, an adipocyte-derived plasma protein, has been shown to play an important role in the regulation of fatty acid and glucose metabolism. Adiponectin enhances fatty acid oxidation both in skeletal and cardiac muscle as well as in the liver, thus reducing triglyceride content in these tissues. Moreover, it stimulates glucose uptake by skeletal and cardiac muscle, and inhibits glucose production by the liver; consequently decreasing blood glucose levels. This review focuses on the molecular mechanisms underlying adiponectin effects on carbohydrate and lipid metabolism in skeletal muscle, cardiac muscle and liver.
脂联素是一种由脂肪细胞分泌的血浆蛋白，已被证明在脂肪酸和葡萄糖代谢的调节中发挥重要作用。脂联素可增强骨骼肌、心肌以及肝脏中的脂肪酸氧化，从而降低这些组织中的甘油三酯含量。此外，它还能刺激骨骼肌和心肌摄取葡萄糖，并抑制肝脏生成葡萄糖，进而降低血糖水平。本综述重点关注脂联素对骨骼肌、心肌和肝脏中碳水化合物及脂质代谢影响的分子机制。
