Tanaka T, Toda T, Kurai K, Kunito S, Yamshita T, Monna T, Matsui T, Nishiguchi S, Kuroki T, Otani S
Department of Public Health, Osaka City University Medical School.
Arukoru Kenkyuto Yakubutsu Ison. 1991 Oct;26(5):380-90.
The effects of a single ethanol administration on liver weight gain, RNA synthesis, DNA synthesis, and polyamine metabolism as parameters of liver regeneration in rat liver after partial hepatectomy were studied. Ethanol, given 1 hr before partial hepatectomy at the dose of 3 g/kg, inhibited RNA synthesis 4 hr after partial hepatectomy and DNA synthesis 24 hr after partial hepatectomy in the liver, but did not affect liver weight gain. Further, we studied the effects of a single ethanol administration on polyamine metabolism in order to elucidate the mechanism of the inhibition of liver regeneration by ethanol. Ethanol inhibited the increase in the putrescine level in the liver 4 and 8 hr after surgery, which was a metabolic product of ornithine decarboxylase. But spermidine and spermidine levels in the liver were not affected by ethanol administration. Hepatic spermidine N1-acetyl transferase activity increased by ethanol administration 6 hr after partial hepatectomy in compensation for the suppression of putrescine. Judging from these results, a single dose of ethanol inhibited liver regeneration polyamine metabolism after partial hepatectomy in rats.
研究了单次给予乙醇对大鼠部分肝切除术后肝脏再生参数（肝脏重量增加、RNA合成、DNA合成和多胺代谢）的影响。在部分肝切除术前1小时以3 g/kg的剂量给予乙醇，可抑制部分肝切除术后4小时肝脏中的RNA合成以及术后24小时的DNA合成，但不影响肝脏重量增加。此外，为了阐明乙醇抑制肝脏再生的机制，我们研究了单次给予乙醇对多胺代谢的影响。乙醇抑制了术后4小时和8小时肝脏中腐胺水平的升高，腐胺是鸟氨酸脱羧酶的代谢产物。但肝脏中的亚精胺和精胺水平不受乙醇给药的影响。部分肝切除术后6小时，乙醇给药使肝脏亚精胺N1-乙酰转移酶活性增加，以补偿腐胺的抑制作用。从这些结果来看，单剂量乙醇抑制了大鼠部分肝切除术后肝脏再生的多胺代谢。
