Rumawas Marcella E, McKeown Nicola M, Rogers Gail, Meigs James B, Wilson Peter W F, Jacques Paul F
Nutritional Epidemiology Program, JM USDA HNRC at Tufts University, Boston, MA 02111-1524, USA.
J Am Coll Nutr. 2006 Dec;25(6):486-92. doi: 10.1080/07315724.2006.10719563.
Higher dietary intake of magnesium may protect against development of type 2 diabetes. The aim of this study was to examine the association between dietary magnesium intake and metabolic risk factors for diabetes.
We examined cross-sectional associations between magnesium intake and fasting glucose and insulin, 2-hour post-challenge plasma glucose and insulin, and insulin resistance assessed by the homeostasis model (HOMA-IR) in 1223 men and 1485 women without diabetes from the Framingham Offspring cohort. Magnesium intake was assessed by a food frequency questionnaire and magnesium intake was categorized into quintile categories. Geometric mean insulin, glucose, 2-hour post challenge plasma glucose and insulin concentrations and HOMA-IR were estimated across quintile categories of magnesium intake using Generalized Linear Models.
After adjustment for potential confounding factors, magnesium intake was inversely associated with fasting insulin (mean: 29.9 vs 26.7 microU/mL in the lowest vs highest quintiles of magnesium intake; P trend <0.001), post-glucose challenge plasma insulin (86.4 vs 72 microU/mL; P trend <0.001), and HOMA-IR (7.0 vs 6.2; P trend <0.001). No significant association was found between magnesium intake and fasting glucose or 2-hour post challenge glucose.
Improved insulin sensitivity may be one mechanism by which higher dietary magnesium intake may reduce the risk of developing type 2 DM.
增加膳食镁摄入量可能预防2型糖尿病的发生。本研究旨在探讨膳食镁摄入量与糖尿病代谢危险因素之间的关联。
我们在弗雷明汉后代队列中，对1223名男性和1485名无糖尿病女性进行了横断面研究，分析镁摄入量与空腹血糖和胰岛素、餐后2小时血浆葡萄糖和胰岛素，以及通过稳态模型评估的胰岛素抵抗（HOMA-IR）之间的关联。通过食物频率问卷评估镁摄入量，并将镁摄入量分为五个五分位数类别。使用广义线性模型估计不同镁摄入量五分位数类别的几何平均胰岛素、葡萄糖、餐后2小时血浆葡萄糖和胰岛素浓度以及HOMA-IR。
在调整潜在混杂因素后，镁摄入量与空腹胰岛素（最低与最高五分位数的平均值：29.9对26.7微单位/毫升；P趋势<0.001）、葡萄糖耐量试验后血浆胰岛素（86.4对72微单位/毫升；P趋势<0.001）和HOMA-IR（7.0对6.2；P趋势<0.001）呈负相关。未发现镁摄入量与空腹血糖或餐后2小时血糖之间存在显著关联。
改善胰岛素敏感性可能是高膳食镁摄入量降低2型糖尿病发生风险的一种机制。
