Yoshida Makiko, Booth Sarah L, Meigs James B, Saltzman Edward, Jacques Paul F
Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, MA 02111, USA.
Am J Clin Nutr. 2008 Jul;88(1):210-5. doi: 10.1093/ajcn/88.1.210.
Limited evidence suggests that vitamin K may have a beneficial role in glucose homeostasis. No observational data exist on the associations between vitamin K intake and insulin sensitivity.
We aimed to examine associations between vitamin K intake and measures of insulin sensitivity and glycemic status in men and women aged 26-81 y.
We assessed the cross-sectional associations of self-reported phylloquinone (vitamin K(1)) intake with insulin sensitivity and glycemic status in the Framingham Offspring Cohort. Dietary and supplemental phylloquinone intakes were assessed by using a food-frequency questionnaire. Insulin sensitivity was measured by fasting and 2-h post-oral-glucose-tolerance test (OGTT) insulin, the homeostasis model assessment of insulin resistance (HOMA-IR), and the insulin sensitivity index (ISI(0,120)). Glycemic status was assessed by fasting and 2-h post-OGTT glucose and glycated hemoglobin (HbA(1c)).
Higher phylloquinone intake was associated with greater insulin sensitivity and glycemic status, as measured by 2-h post-OGTT insulin and glucose and ISI(0,120), after adjustment for age, sex, waist circumference, lifestyle characteristics, and diet quality [2-h post-OGTT insulin: lowest and highest quintile, 81.0 and 72.7 microU/mL, respectively (P for trend = 0.003); 2-h post-OGTT glucose: 106.3 and 101.9 mg/dL, respectively (P for trend = 0.009); ISI(0,120): 26.3 and 27.3 mg L(2)/mmol mU min (P for trend = 0.009)]. Phylloquinone intake was not associated with fasting insulin and glucose concentrations, HOMA-IR, or HbA(1c).
Our findings support a potential beneficial role for phylloquinone in glucose homeostasis in men and women.
有限的证据表明维生素K可能在葡萄糖稳态中发挥有益作用。关于维生素K摄入量与胰岛素敏感性之间的关联，尚无观察性数据。
我们旨在研究26至81岁男性和女性中维生素K摄入量与胰岛素敏感性及血糖状态指标之间的关联。
我们在弗雷明汉后代队列中评估了自我报告的叶绿醌（维生素K1）摄入量与胰岛素敏感性及血糖状态的横断面关联。通过食物频率问卷评估膳食和补充性叶绿醌摄入量。通过空腹及口服葡萄糖耐量试验（OGTT）后2小时胰岛素、胰岛素抵抗稳态模型评估（HOMA-IR）以及胰岛素敏感性指数（ISI(0,120)）来测量胰岛素敏感性。通过空腹及OGTT后2小时血糖和糖化血红蛋白（HbA1c）评估血糖状态。
在调整年龄、性别、腰围、生活方式特征和饮食质量后，较高的叶绿醌摄入量与更高的胰岛素敏感性及血糖状态相关，这通过OGTT后2小时胰岛素和血糖以及ISI(0,120)来衡量[OGTT后2小时胰岛素：最低和最高五分位数分别为81.0和72.7微单位/毫升（趋势P值=0.003）；OGTT后2小时血糖：分别为106.3和101.9毫克/分升（趋势P值=0.009）；ISI(0,120)：26.3和27.3毫克·升²/毫摩尔·毫单位·分钟（趋势P值=0.009）]。叶绿醌摄入量与空腹胰岛素和血糖浓度、HOMA-IR或HbA1c无关。
我们的研究结果支持叶绿醌在男性和女性葡萄糖稳态中可能具有有益作用。
