饮食镁与糖尿病及相关风险因素中的遗传相互作用：当前知识简述。
Dietary magnesium and genetic interactions in diabetes and related risk factors: a brief overview of current knowledge.
机构信息
Department of Nutrition, Harvard School of Public Health, 677 Huntington Avenue, Building 2, Boston, MA 02115, USA.
出版信息
Nutrients. 2013 Dec 6;5(12):4990-5011. doi: 10.3390/nu5124990.
Abstract
Nutritional genomics has exploded in the last decade, yielding insights-both nutrigenomic and nutrigenetic-into the physiology of dietary interactions and our genes. Among these are insights into the regulation of magnesium transport and homeostasis and mechanisms underlying magnesium's role in insulin and glucose handling. Recent observational evidence has attempted to examine some promising research avenues on interaction between genetics and dietary magnesium in relation to diabetes and diabetes risk factors. This brief review summarizes the recent evidence on dietary magnesium's role in diabetes and related traits in the presence of underlying genetic risk, and discusses future potential research directions.
摘要
营养基因组学在过去十年中迅速发展，为饮食相互作用和我们的基因的生理学提供了见解——包括营养基因组学和营养遗传学方面的见解。其中包括对镁运输和稳态调节的认识，以及镁在胰岛素和葡萄糖处理中的作用的机制。最近的观察性证据试图研究一些有前途的研究途径，即遗传和饮食镁之间的相互作用与糖尿病和糖尿病危险因素的关系。这篇简短的综述总结了在存在潜在遗传风险的情况下，饮食镁在糖尿病和相关特征中的作用的最新证据，并讨论了未来潜在的研究方向。
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