Picó C, Pons A, Gianotti M, Palou A
Dpt. de Biologia fonamental, Universitat de les Illes Balears, Palma de Mallorca, Spain.
Arch Int Physiol Biochim Biophys. 1991 Aug;99(4):345-8. doi: 10.3109/13813459109146948.
We have previously reported that blood urea and blood cell amino acids levels are reduced in rats obese by feeding a palatable cafeteria diet. In order to distinguish whether these changes result from the altered diet, or from the obesity per se, we have studied cafeteria fed rats after returning to standard diet. As in previous studies, obesity induced by cafeteria feeding (for 90 days) was maintained when the cafeteria diet was removed and rats were fed standard diet only. After removal of the cafeteria diet, blood urea levels of 24 h starved obese rats were lower (23%) than those of starved control rats. Blood cell amino acid levels of obese were lower than control ones from day 50 onwards, during and after cafeteria feeding (21% lower on day 100 of life), and thus coincided with divergence of body weights; these differences were maintained despite removal of cafeteria diet. The effects of starvation on plasma amino acid levels were more marked in obese than control rats, during and after cafeteria feeding. Thus the effects on blood amino acids and urea levels in cafeteria diet induced obese rats are related to the obese status rather than to the diet composition.
我们之前曾报道，通过喂食美味自助餐饮食而肥胖的大鼠，其血尿素和血细胞氨基酸水平会降低。为了区分这些变化是由饮食改变引起的，还是由肥胖本身引起的，我们对恢复标准饮食后的自助餐喂养大鼠进行了研究。与之前的研究一样，当去除自助餐饮食并仅给大鼠喂食标准饮食时，由自助餐喂养（90天）诱导的肥胖得以维持。去除自助餐饮食后，饥饿24小时的肥胖大鼠的血尿素水平低于饥饿的对照大鼠（低23%）。从第50天起，在自助餐喂养期间及之后，肥胖大鼠的血细胞氨基酸水平低于对照大鼠（在出生第100天时低21%），因此与体重差异一致；尽管去除了自助餐饮食，这些差异仍得以维持。在自助餐喂养期间及之后，饥饿对肥胖大鼠血浆氨基酸水平的影响比对对照大鼠更明显。因此，自助餐饮食诱导的肥胖大鼠血氨基酸和尿素水平的变化与肥胖状态有关，而不是与饮食组成有关。
