Schindl R, Romanin C
Institute for Biophysics, University of Linz, A-4040 Linz, Austria.
Biochem Soc Trans. 2007 Feb;35(Pt 1):84-5. doi: 10.1042/BST0350084.
The large family of mammalian TRP (transient receptor potential) ion channels encompasses diverse sensory functions. TRP proteins consist of six transmembrane domains, with a pore-loop motif between the fifth and sixth domains and cytosolic N- and C-termini. The intracellular strands not only interact with various proteins and lipids, but also include essential multimerization regions. This review summarizes the current knowledge of the intrinsic assembly domains that assure tetrameric TRP channel formation.
哺乳动物的瞬时受体电位（TRP）离子通道大家族具有多种感觉功能。TRP蛋白由六个跨膜结构域组成，在第五和第六个结构域之间有一个孔环基序，以及胞质N端和C端。细胞内链不仅与各种蛋白质和脂质相互作用，还包括重要的多聚化区域。本综述总结了目前关于确保TRP通道形成四聚体的内在组装结构域的知识。
