瞬时受体电位通道：概述

TRP channels: an overview.

作者信息

Pedersen Stine Falsig, Owsianik Grzegorz, Nilius Bernd

机构信息

Department of Biochemistry, Institute for Molecular Biology and Physiology, University of Copenhagen, Denmark.

出版信息

Cell Calcium. 2005 Sep-Oct;38(3-4):233-52. doi: 10.1016/j.ceca.2005.06.028.

DOI:10.1016/j.ceca.2005.06.028

PMID:16098585

Abstract

The TRP ("transient receptor potential") family of ion channels now comprises more than 30 cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the basis of sequence homology, the TRP family can be divided in seven main subfamilies: the TRPC ('Canonical') family, the TRPV ('Vanilloid') family, the TRPM ('Melastatin') family, the TRPP ('Polycystin') family, the TRPML ('Mucolipin') family, the TRPA ('Ankyrin') family, and the TRPN ('NOMPC') family. The cloning and characterization of members of this cation channel family has exploded during recent years, leading to a plethora of data on the roles of TRPs in a variety of tissues and species, including mammals, insects, and yeast. The present review summarizes the most pertinent recent evidence regarding the structural and functional properties of TRP channels, focusing on the regulation and physiology of mammalian TRPs.

摘要

瞬时受体电位（TRP）离子通道家族目前包含30多种阳离子通道，其中大多数对Ca2+具有通透性，有些还对Mg2+具有通透性。基于序列同源性，TRP家族可分为七个主要亚家族：TRPC（“典型”）家族、TRPV（“香草酸”）家族、TRPM（“褪黑素”）家族、TRPP（“多囊蛋白”）家族、TRPML（“粘脂质”）家族、TRPA（“锚蛋白”）家族和TRPN（“NOMPC”）家族。近年来，这个阳离子通道家族成员的克隆和特性研究激增，产生了大量关于TRP在包括哺乳动物、昆虫和酵母在内的各种组织和物种中的作用的数据。本综述总结了关于TRP通道结构和功能特性的最新相关证据，重点关注哺乳动物TRP的调节和生理学。