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何种酒精摄入量水平对老年人有害?美国和英国全国队列中的机能与死亡率

What level of alcohol consumption is hazardous for older people? Functioning and mortality in U.S. and English national cohorts.

作者信息

Lang Iain, Guralnik Jack, Wallace Robert B, Melzer David

机构信息

Epidemiology and Public Health Group, Peninsula Medical School, Exeter, UK.

出版信息

J Am Geriatr Soc. 2007 Jan;55(1):49-57. doi: 10.1111/j.1532-5415.2006.01007.x.

Abstract

OBJECTIVES

To estimate disability plus mortality risks in older people according to level of alcohol intake.

DESIGN

Two population-based cohort studies.

SETTING

The Health and Retirement Study (United States) and the English Longitudinal Study of Aging (England).

PARTICIPANTS

Thirteen thousand three hundred thirty-three individuals aged 65 and older followed for 4 to 5 years.

MEASUREMENTS

Difficulties with activities of daily living (ADLs), instrumental activities of daily living (IADLs), poor cognitive function, and mortality.

RESULTS

One-tenth (10.8%) of U.S. men, 28.6% of English men, 2.9% of U.S. women, and 10.3% of English women drank more than the U.S. National Institute on Alcohol Abuse and Alcoholism recommended limit for people aged 65 and older. Odds ratios (ORs) of disability, or disability plus mortality, in subjects drinking an average of more than one to two drinks per day were similar to ORs in subjects drinking an average of more than none to one drink per day. For example, those drinking more than one to two drinks per day at baseline had an OR of 1.0 (95% confidence interval (CI)=0.8-1.2) for ADL problems, 0.7 (95% CI=0.6-1.0) for IADL problems, and 0.8 (95% CI=0.6-1.1) for poor cognitive function. Findings were robust across alternative models. The shape of the relationship between alcohol consumption and risk of disability was similar in men and women.

CONCLUSION

Functioning and mortality outcomes in older people with alcohol intakes above U.S. recommended levels for the old but within recommendations for younger adults are not poor. More empirical evidence of net benefit is needed to support screening and intervention efforts in community-living older people with no specific contraindications who drink more than one to two drinks per day.

摘要

目的

根据酒精摄入量估计老年人的残疾及死亡风险。

设计

两项基于人群的队列研究。

地点

健康与退休研究(美国)和英国老龄化纵向研究(英国)。

参与者

13333名65岁及以上的个体,随访4至5年。

测量指标

日常生活活动(ADL)困难、工具性日常生活活动(IADL)困难、认知功能差及死亡率。

结果

美国男性中有十分之一(10.8%)、英国男性中有28.6%、美国女性中有2.9%、英国女性中有10.3%的饮酒量超过了美国国立酒精滥用与酒精中毒研究所为65岁及以上人群推荐的限量。平均每天饮酒超过一到两杯的受试者出现残疾或残疾加死亡的比值比(OR)与平均每天饮酒超过零到一杯的受试者相似。例如,在基线时每天饮酒超过一到两杯的受试者出现ADL问题的OR为1.0(95%置信区间(CI)=0.8 - 1.2),出现IADL问题的OR为0.7(95% CI = 0.6 - 1.0),认知功能差的OR为0.8(95% CI = 0.6 - 1.1)。在不同模型中研究结果均很稳健。男性和女性饮酒量与残疾风险之间的关系形状相似。

结论

酒精摄入量高于美国老年人推荐水平但在年轻人推荐范围内的老年人,其功能和死亡率结果并不差。对于社区中无特定禁忌且每天饮酒超过一到两杯的老年人,需要更多关于净益处的实证证据来支持筛查和干预措施。

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