Pérez de los Cobos José, Siñol Núria, Trujols Joan, del Río Elisabeth, Bañuls Enrique, Luquero Elena, Menoyo Anna, Queraltó Josep Maria, Baiget Montserrat, Alvarez Enric
Addictive Behaviors Unit (Psychiatry Department), Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M. Claret 167, 08025 Barcelona, Spain.
Drug Alcohol Depend. 2007 Jul 10;89(2-3):190-4. doi: 10.1016/j.drugalcdep.2006.12.018. Epub 2007 Jan 17.
The activity of cytochrome P-450 enzyme 2D6 (CYP2D6) could be related to heroin-dependent patient satisfaction with methadone maintenance treatment. We sought to compare satisfaction with the usual methadone treatment in patients who are ultrarapid, extensive or poor metabolizers, according to CYP2D6 genotyping.
Two hundred and five heroin-dependent patients filled out the Verona Service Satisfaction Scale for methadone maintenance treatment (VSSS-MT), before CYP2D6 genotyping.
VSSS-MT overall scores were comparable in the poor metabolizer (N=9) and extensive metabolizer (N=185) groups, although they were higher in poor metabolizers and extensive metabolizers taken together than in the ultrarapid metabolizers (N=11) (p<0.003). Likewise, ultrarapid metabolizers scored higher than the rest of the sample on the VSSS-MT Basic Interventions subscale (p<001). Regarding this subscale, no poor metabolizers felt dissatisfied, and ultrarapid metabolizer males (N=7) reported lower satisfaction than ultrarapid metabolizer females (N=4) (p<0.022). Ultrarapid metabolizer genotype accounted for 4.2% of the variance on the VSSS-MT total scores, and 5.0% on the Basic Intervention scores.
Heroin-dependent patients who are CYP2D6 ultrarapid metabolizers according to genotyping present deficient satisfaction with methadone maintenance treatment.
细胞色素P-450酶2D6（CYP2D6）的活性可能与海洛因依赖患者对美沙酮维持治疗的满意度有关。我们试图根据CYP2D6基因分型，比较超快代谢型、广泛代谢型或慢代谢型患者对常规美沙酮治疗的满意度。
205名海洛因依赖患者在进行CYP2D6基因分型之前，填写了美沙酮维持治疗的维罗纳服务满意度量表（VSSS-MT）。
慢代谢型（N=9）和广泛代谢型（N=185）组的VSSS-MT总分相当，尽管慢代谢型和广泛代谢型患者的总分高于超快代谢型患者（N=11）（p<0.003）。同样，超快代谢型患者在VSSS-MT基本干预子量表上的得分高于其他样本（p<0.01）。关于这个子量表，没有慢代谢型患者感到不满意，超快代谢型男性（N=7）报告的满意度低于超快代谢型女性（N=4）（p<0.022）。超快代谢型基因型在VSSS-MT总分的方差中占4.2%，在基本干预得分的方差中占5.0%。
根据基因分型，CYP2D6超快代谢型的海洛因依赖患者对美沙酮维持治疗的满意度较低。
