Lin Kaili, Chang Jiang, Cheng Rongming
Center of Functional Nanomaterials and Devices, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, PR China.
Acta Biomater. 2007 Mar;3(2):271-6. doi: 10.1016/j.actbio.2006.11.003. Epub 2007 Jan 17.
In this paper, fiber-like and dispersible tobermorite (Ca(5)(Si(6)O(16))(OH)(2).4H(2)O), 80-120 nm in diameter and up to tens of micrometers in length was prepared by a hydrothermal microemulsion method. In vitro bioactivity of the nanofibers were evaluated by examing the hydroxyapatite (HAp) forming ability on the surface after soaking in simulated body fluid (SBF) for various periods. After soaking in SBF, the nanofibers were completely covered by bonelike hydroxycarbonate apatite (HCA) layers, and the nanofibers after soaking still kept stability in fibrous morphology. The dissolution of the nanofibers reached about 24.5% after soaking in SBF for 14 days. The results suggested that the tobermorite nanofibers exhibited certain desirable characteristics, including bioactivity, degradability and stability in morphology, and are a potential candidate for a reinforcement material in the development of novel bioactive and degradable composites for biomedical applications.
本文采用水热微乳液法制备了直径为80 - 120 nm、长度达数十微米的纤维状且可分散的雪硅钙石（Ca(5)(Si(6)O(16))(OH)(2).4H(2)O）。通过检测纳米纤维在模拟体液（SBF）中浸泡不同时间后表面形成羟基磷灰石（HAp）的能力，对其体外生物活性进行了评估。浸泡在SBF中后，纳米纤维完全被类骨羟基碳酸磷灰石（HCA）层覆盖，浸泡后的纳米纤维在纤维形态上仍保持稳定。在SBF中浸泡14天后，纳米纤维的溶解率达到约24.5%。结果表明，雪硅钙石纳米纤维具有某些理想的特性，包括生物活性、可降解性和形态稳定性，是开发用于生物医学应用的新型生物活性和可降解复合材料的增强材料的潜在候选者。
