Sheikh F A, Kanjwal M A, Macossay J, Barakat N A M, Kim H Y
Department of Chemistry, University of Texas Pan American, Edinburg, TX 78539, USA.
Technical University of Denmark, DTU Food, Soltofts Plads, B 227. 2800. Kgs. Lyngby, Denmark.
Express Polym Lett. 2012;6(1). doi: 10.3144/expresspolymlett.2012.5.
In the present study, we had introduced polyurethane (PU) nanofibers that contain hydroxyapatite (HAp) nanoparticles (NPs) as a result of an electrospinning process. A simple method that does not depend on additional foreign chemicals had been employed to synthesize HAp NPs through the calcination of bovine bones. Typically, a colloidal gel consisting of HAp/PU had been electrospun to form nanofibers. In this communication, physiochemical aspects of prepared nanofibers were characterized by FE-SEM, TEM and TEM-EDS, which confirmed that nanofibers were well-oriented and good dispersion of HAp NPs, over the prepared nanofibers. Parameters, affecting the utilization of the prepared nanofibers in various nano-biotechnological fields have been studied; for instance, the bioactivity of the produced nanofiber mats was investigated while incubating in simulated body fluid (SBF). The results from incubation of nanofibers, indicated that incorporation of HAp strongly activates the precipitation of the apatite-like particles, because of the HAp NPs act as seed, that accelerate crystallization of the biological HAp from the utilized SBF.
在本研究中，我们通过静电纺丝工艺引入了含有羟基磷灰石（HAp）纳米颗粒（NPs）的聚氨酯（PU）纳米纤维。采用了一种不依赖额外外来化学物质的简单方法，通过煅烧牛骨来合成HAp NPs。通常，将由HAp/PU组成的胶体凝胶进行静电纺丝以形成纳米纤维。在本通讯中，通过场发射扫描电子显微镜（FE-SEM）、透射电子显微镜（TEM）和透射电子显微镜-能谱仪（TEM-EDS）对制备的纳米纤维的物理化学特性进行了表征，证实纳米纤维取向良好且HAp NPs在制备的纳米纤维上分散良好。研究了影响所制备的纳米纤维在各种纳米生物技术领域应用的参数；例如，在模拟体液（SBF）中孵育时研究了所制备的纳米纤维垫的生物活性。纳米纤维孵育的结果表明，由于HAp NPs作为晶种，能加速从所用SBF中析出生物HAp的结晶，因此HAp的掺入强烈激活了类磷灰石颗粒的沉淀。
