Lagadic Laurent, Coutellec Marie-Agnès, Caquet Thierry
UMR985 INRA-Agrocampus Ecobiologie et Qualité des Hydrosystèmes Continentaux, Equipe Ecotoxicologie et Qualité des Milieux aquatiques, 65 Rue de Saint-Brieuc, F-35042 Rennes Cedex, France.
Ecotoxicology. 2007 Feb;16(1):45-59. doi: 10.1007/s10646-006-0114-0.
As compared to other groups of aquatic gastropods, documented examples of endocrine disruption in pulmonates are rather limited. This is quite surprising because the endocrine control of physiological functions has been extensively studied in these animals. In the model-species Lymnaea stagnalis, the neurohormonal regulation of reproduction has been thoroughly investigated, and the primary structure of several peptides and receptors involved in endocrine processes has been established. However, the use of this knowledge has been fairly limited in the context of ecotoxicology, to investigate the effects of endocrine-disrupting chemicals. The present review summarizes the main and more recent findings on the neuroendocrine control of reproduction in aquatic pulmonate snails (Basommatophora). It then comprehensively describes selected in vivo laboratory and semi-field studies which provide evidence for possible endocrine disrupting effects of estrogenic and androgenic test compounds [e.g., ethynylestradiol, methyltestosterone (MT)], and of environmental contaminants [e.g., cadmium (Cd), tributyltin (TBT), and nonylphenol (NP), pesticides]. Finally, challenging perspectives for future research are discussed.
与其他水生腹足纲动物群体相比，有关肺螺亚纲动物内分泌干扰的实例记录相当有限。这颇为令人惊讶，因为这些动物生理功能的内分泌控制已得到广泛研究。在模式物种椎实螺中，繁殖的神经激素调节已得到深入研究，并且已确定了参与内分泌过程的几种肽和受体的一级结构。然而，在生态毒理学背景下，利用这些知识来研究内分泌干扰化学物质的影响相当有限。本综述总结了关于水生肺螺亚纲蜗牛（基眼目）繁殖的神经内分泌控制的主要及最新研究结果。然后全面描述了选定的体内实验室和半野外研究，这些研究为雌激素和雄激素测试化合物[如乙炔雌二醇、甲基睾酮（MT）]以及环境污染物[如镉（Cd）、三丁基锡（TBT）和壬基酚（NP）、农药]可能的内分泌干扰作用提供了证据。最后，讨论了未来研究面临的挑战和前景。
