新型抗人破骨细胞单克隆抗体的制备与特性分析
Production and characterization of new monoclonal antibodies to human osteoclasts.
作者信息
Nelson P N, Pringle J A, Chambers T J
机构信息
Department of Histopathology, St. George's Hospital Medical School, London, U.K.
出版信息
Calcif Tissue Int. 1991 Nov;49(5):317-20. doi: 10.1007/BF02556253.
Two monoclonal antibodies raised against human osteoclastoma were found to show antiosteoclastic activity on frozen sections of tumor. Immunoreactivity was localized on the membrane surface. These antibodies exhibited no activity against tissue macrophages and human visceral tissue except kidney, where they stained tubules but not glomeruli. In addition, no activity was observed against rabbit or rat osteoclasts, suggesting that they might react with unique epitopes on human osteoclasts.
发现两种针对人骨巨细胞瘤产生的单克隆抗体在肿瘤冰冻切片上显示出抗破骨细胞活性。免疫反应性定位于细胞膜表面。这些抗体除了对肾脏（在肾脏中它们使肾小管染色但不使肾小球染色）外，对组织巨噬细胞和人体内脏组织没有活性。此外，未观察到对兔或大鼠破骨细胞的活性，这表明它们可能与人破骨细胞上独特的表位发生反应。
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