酸性磷酸酶
Acid phosphatases.
作者信息
Bull H, Murray P G, Thomas D, Fraser A M, Nelson P N
机构信息
Human and Clinical Research Group, School of Nursing, University of Nottingham, Derbyshire Royal Infirmary, Derby DE1 2QY, UK.
出版信息
Mol Pathol. 2002 Apr;55(2):65-72. doi: 10.1136/mp.55.2.65.
Abstract
Acid phosphatases (APs) are a family of enzymes that are widespread in nature, and can be found in many animal and plant species. Mystery surrounds the precise functional role of these molecular facilitators, despite much research. Yet, paradoxically, human APs have had considerable impact as tools of clinical investigation and intervention. One particular example is tartrate resistant acid phosphatase, which is detected in the serum in raised amounts accompanying pathological bone resorption. This article seeks to explore the identity and diversity of APs, and to demonstrate the relation between APs, human disease, and clinical diagnosis.
摘要
酸性磷酸酶（APs）是一类在自然界广泛存在的酶，可在许多动植物物种中发现。尽管进行了大量研究，但这些分子促进剂的确切功能作用仍笼罩在谜团之中。然而，矛盾的是，人类酸性磷酸酶作为临床研究和干预工具产生了相当大的影响。一个特别的例子是抗酒石酸酸性磷酸酶，在病理性骨吸收时血清中该酶含量会升高。本文旨在探讨酸性磷酸酶的特性和多样性，并阐明酸性磷酸酶、人类疾病和临床诊断之间的关系。
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