Seliskar A, Nemec A, Roskar T, Butinar J
Clinic for Small Animal Medicine and Surgery, Veterinary Faculty, University of Ljubljana, Gerbiceva 60, 1000 Ljubljana, Slovenia.
Vet Rec. 2007 Jan 20;160(3):85-91. doi: 10.1136/vr.160.3.85.
The cardiorespiratory parameters, the depth of anaesthesia and the quality of recovery were evaluated in six spontaneously breathing dogs that had been premedicated with medetomidine (40 microg/kg, supplemented with 20 microg/kg an hour later), administered with either propofol (1 mg/kg followed by 0.15 mg/kg/minute, intravenously), or with ketamine (1 mg/kg followed by 2 mg/kg/hour, intravenously) and propofol (0.5 mg/kg followed by 0.075 mg/kg/minute, intravenously). The dogs' heart rate and mean arterial blood pressure were higher and their minute volume of respiration and temperature were lower when they were anaesthetised with propofol plus ketamine, and a progressive hypercapnia leading to respiratory acidosis was more pronounced. When the dogs were anaesthetised with propofol/ketamine they recovered more quickly, but suffered some unwanted side effects. When the dogs were anaesthetised with propofol alone they recovered more slowly but uneventfully.
对6只自主呼吸的犬进行了评估，这些犬预先用美托咪定（40微克/千克，1小时后补充20微克/千克）进行了预处理，然后分别静脉注射丙泊酚（1毫克/千克，随后以0.15毫克/千克/分钟的速度静脉滴注），或氯胺酮（1毫克/千克，随后以2毫克/千克/小时的速度静脉滴注）和丙泊酚（0.5毫克/千克，随后以0.075毫克/千克/分钟的速度静脉滴注）。当用丙泊酚加氯胺酮麻醉时，犬的心率和平均动脉血压较高，而每分通气量和体温较低，并且导致呼吸性酸中毒的进行性高碳酸血症更为明显。当犬用丙泊酚/氯胺酮麻醉时，它们恢复得更快，但出现了一些不良副作用。当犬仅用丙泊酚麻醉时，它们恢复得较慢但过程平稳。
