Abdel-Hady Abdelnaser Abdelmoneim Azab, Abdelbasset Khaled M, Soliman Ahmed S
Department of Surgery, Anaesthesiology and Radiology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
Department of Surgery, Anaesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt.
EXCLI J. 2017 May 22;16:770-779. doi: 10.17179/excli2017-298. eCollection 2017.
The goal of the present study is to design a good anaesthetic program for dogs which can lead to optimal anaesthesia with no or minimal post-operative adverse effects. For this purpose, we designed two anaesthetic combinations and compared their effects in Mongrel dogs: combination 'A' consisting of atropine, xylazine, ketamine plus propofol, and combination 'B' consisting of atropine, diazepam, ketamine plus propofol. The onset and duration of anaesthesia induction, the duration of maintenance as well as the period of recovery were recorded and compared for both combinations. Furthermore, heart rate, respiratory rate, body temperature as well as blood picture were analyzed before and after administration of the proposed anaesthetic regimens. Administration of combination 'A' lead to rapid onset, within seconds, and induction of anaesthesia. The anaesthetic effect was maintained for approximately 29 minutes after injection of propofol. This was followed by very smooth recovery within approximately 68 minutes after induction of anaesthesia. In contrast, a less efficient induction and maintenance of anaesthesia as well as individual variability was observed after administration of combination 'B'. Approximately 14 minutes were needed for anaesthesia induction, which was maintained for 23 minutes after injection of propofol. Furthermore, administration of combination 'B' was associated with alterations in heart rate, body temperature and hematological picture. In conclusion, our results revealed that combined administration of atropine, xylazine, ketamine plus propofol (combination 'A') is considered satisfactory for anaesthesia in dogs with minimal post-operative side effects.
本研究的目的是为犬设计一种良好的麻醉方案，该方案可实现最佳麻醉效果，且术后不良反应极少或没有。为此，我们设计了两种麻醉组合，并比较它们在杂种犬中的效果：组合“A”由阿托品、赛拉嗪、氯胺酮加丙泊酚组成，组合“B”由阿托品、地西泮、氯胺酮加丙泊酚组成。记录并比较了两种组合的麻醉诱导起效时间和持续时间、维持时间以及恢复时间。此外，在给予建议的麻醉方案前后，分析了心率、呼吸频率、体温以及血常规。给予组合“A”后，数秒内即可快速起效并诱导麻醉。注射丙泊酚后，麻醉效果维持约29分钟。随后，麻醉诱导后约68分钟内恢复非常平稳。相比之下，给予组合“B”后，麻醉诱导和维持效果较差，且存在个体差异。麻醉诱导大约需要14分钟，注射丙泊酚后维持23分钟。此外，给予组合“B”与心率、体温和血液学指标的改变有关。总之，我们的结果表明，阿托品、赛拉嗪、氯胺酮加丙泊酚联合给药（组合“A”）对犬麻醉而言是令人满意的，术后副作用极小。
