Ko Jeff C H, Payton Mark E, White Alison G, Galloway David S, Inoue Tomohito
Department of Veterinary Clinical Sciences, College of Arts and Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA.
J Am Anim Hosp Assoc. 2006 Jan-Feb;42(1):18-27. doi: 10.5326/0420018.
This crossover study tested the hypothesis that both diazepam and microdose medetomidine would comparably reduce the amount of propofol required to induce sedation. Four different medications, namely high-dose diazepam (0.4 mg/kg intravenously [IV]), low-dose diazepam (0.2 mg/kg IV), medetomidine (1 mug/kg IV), and placebo (0.5 mL physiological saline IV) were followed by propofol (8 mg/kg IV) titrated to a point where intubation could be performed. The effects of medetomidine were comparable to the effects of high-dose diazepam and significantly better than the effects of low-dose diazepam or placebo. Dogs in all treatment groups had transient hypoxemia, and induction and recovery qualities were similar.
地西泮和小剂量美托咪定在减少诱导镇静所需丙泊酚用量方面具有可比性。四种不同药物，即高剂量地西泮（静脉注射0.4mg/kg）、低剂量地西泮（静脉注射0.2mg/kg）、美托咪定（静脉注射1μg/kg）和安慰剂（静脉注射0.5mL生理盐水），随后静脉注射丙泊酚（8mg/kg）并滴定至可进行插管的程度。美托咪定的效果与高剂量地西泮的效果相当，且明显优于低剂量地西泮或安慰剂的效果。所有治疗组的犬均出现短暂性低氧血症，诱导和恢复质量相似。
