人类免疫缺陷病毒感染对丙型肝炎病毒感染患者的影响。

Impact of human immunodeficiency virus infection in patients infected with the hepatitis C virus.

作者信息

Valle Tovo Cristiane, Alves de Mattos Angelo, Ribeiro de Souza Andréa, Ferrari de Oliveira Rigo Juliana, Lerias de Almeida Paulo Roberto, Galperim Bruno, Riegel Santos Breno

机构信息

Hospital Nossa Senhora da Conceição (HNSC), Porto Alegre, Brazil.

出版信息

Liver Int. 2007 Feb;27(1):40-6. doi: 10.1111/j.1478-3231.2006.01344.x.

DOI:10.1111/j.1478-3231.2006.01344.x

PMID:17241379

Abstract

BACKGROUND/AIMS: The objective of the present study is to evaluate the impact of human immunodeficiency virus (HIV) in patients with hepatitis C virus (HCV) infection.

METHODS

Three different groups of patients were considered: group 1, 385 HCV/HIV coinfected; group 2, 198 HIV monoinfected; and group 3, 311 HCV monoinfected. Demographic and epidemiological data were collected. Blood tests included anti-HCV, HCV-RNA test, genotyping, CD4 cell count, anti-HIV, and HIV viral load. Treatment with interferon and ribavirin was proposed. The fibrosis progression rate was assessed.

RESULTS

The most prevalent risk factor in the group of coinfected was the use of intravenous drugs; in the HIV monoinfection group, heterosexual relations at risk; in the HCV monoinfection group, the transfusion of blood. There was no difference concerning the distribution of genotypes or HCV viral load between groups 1 and 3. Although the mean time of duration of HCV infection was greater in group 3 than in group 1, there was no difference when the fibrosis progression rate was evaluated. The response to treatment was similar.

CONCLUSION

In the present series there was no relevant impact of HCV infection in patients with HIV.

摘要

背景/目的：本研究的目的是评估人类免疫缺陷病毒（HIV）对丙型肝炎病毒（HCV）感染患者的影响。

方法

研究考虑了三组不同的患者：第1组，385例HCV/HIV合并感染患者；第2组，198例HIV单感染患者；第3组，311例HCV单感染患者。收集了人口统计学和流行病学数据。血液检测包括抗-HCV、HCV-RNA检测、基因分型、CD4细胞计数、抗-HIV和HIV病毒载量。建议使用干扰素和利巴韦林进行治疗。评估纤维化进展率。