O'Byrne E M, Goldberg R L, Doughty J R, Wong M, Blancuzzi V, Wilson D, Jeng A Y
CIBA-GEIGY Corporation, Research Department, Summit, NJ 07901.
Agents Actions. 1991 Sep;34(1-2):232-4. doi: 10.1007/BF01993289.
The effect of SP on recombinant human IL-1 alpha-induced cartilage degradation in rabbit knees was investigated. Co-injection of 10 ng IL-1 and 1 micrograms SP did not increase cartilage degradation above the level observed after injection of 10 ng IL-1 alone. Co-injection of 100 ng IL-1 and 150 micrograms Spantide, a potent SP antagonist, did not reduce the level of cartilage degradation. Infusion of 100 ng SP/day for two weeks did not induce cartilage degradation. These observations suggest that cartilage degradation induced by IL-1 is independent of SP concentrations in rabbit knees.
