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新加坡慢性下肢静脉溃疡患者的接触致敏情况

Contact sensitization in patients with chronic venous leg ulcers in Singapore.

作者信息

Lim Kar-Seng, Tang Mark Boon Yang, Goon Anthony Teik Jin, Leow Yung Hian

机构信息

National Skin Centre, 1 Mandalay Road, Singapore 308205, Republic of Singapore.

出版信息

Contact Dermatitis. 2007 Feb;56(2):94-8. doi: 10.1111/j.1600-0536.2007.00987.x.

Abstract

Contact sensitization rates are high in patients with chronic venous leg ulcers. Allergic contact dermatitis poses a significant hindrance to the healing of the wounds. There are no published studies examining the rate of contact sensitization in Asian patients. Our objective was to determine the rate of contact sensitization in patients with chronic venous leg ulcer in Singapore and the variation in the common allergens based on local practices in comparison with Western countries. 44 patients were patch tested to the National Skin Centre standard series, steroid series, medicaments, topical Chinese medicaments, and to modern wound dressings used. The overall rate of contact sensitization was 61.4%. The common allergen groups were topical antibiotics (18.2%) and topical traditional Chinese medicaments (TTCM) (15.9%). Individually, colophony (11.3%), Saw Hong Choon skin ointment (Kam Bo Med, Hong Kong, Hong Kong) (11.3%), Balsam of Peru (9.1%), and povidone iodine (9.1%) were among the most frequent allergens. The sensitization rate among users of TTCM was notably high (41%). A high rate of contact sensitization was found in our study, similar to previous reports from the West. TTCM play a major role as possible allergens in our patients. In Asian patients, a history of its usage should be elicited, and patch testing should include the commonly used TTCM where possible.

摘要

慢性下肢静脉溃疡患者的接触致敏率很高。过敏性接触性皮炎对伤口愈合构成了重大阻碍。目前尚无关于亚洲患者接触致敏率的已发表研究。我们的目的是确定新加坡慢性下肢静脉溃疡患者的接触致敏率,以及与西方国家相比,基于当地实际情况的常见变应原的差异。对44例患者进行了针对国家皮肤中心标准系列、类固醇系列、药物、外用中药以及所用现代伤口敷料的斑贴试验。接触致敏的总体发生率为61.4%。常见的变应原组为外用抗生素(18.2%)和外用中药(15.9%)。单独来看,松香(11.3%)、蛇王软膏(香港金宝药业,香港)(11.3%)、秘鲁香脂(9.1%)和聚维酮碘(9.1%)是最常见的变应原。外用中药使用者中的致敏率显著较高(41%)。在我们的研究中发现了较高的接触致敏率,与西方此前的报道相似。外用中药在我们的患者中作为可能的变应原起着主要作用。在亚洲患者中,应了解其用药史,并且斑贴试验应尽可能包括常用的外用中药。

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