[腿部溃疡患者的斑贴试验，特别关注现代伤口产品]
[Patch testing in patients with leg ulcers with special regard to modern wound products].
作者信息
Reich-Schupke S, Kurscheidt J, Appelhans C, Kreuter A, Altmeyer P, Stücker M
机构信息
Klinik für Dermatologie und Allergologie, Ruhr Universität Bochum, Gudrunstr. 56, 44791, Bochum, Deutschland.
出版信息
Hautarzt. 2010 Jul;61(7):593-7. doi: 10.1007/s00105-010-1972-1.
BACKGROUND
Patients with leg ulcers often have contact sensitizations. Modern wound care products claim low allergic potential.
OBJECT
To analyze the patch test results in leg ulcer patients with focus on modern care wound products.
MATERIAL AND METHODS
95 leg ulcer patients were tested with the standard German patch test series as well as frequently used wound care products.
RESULTS
61% of the patients had at least one positive reaction. Most frequent reactions were seen with tert-butylhydroquinone, povidone iodine, balsam of Peru, a hydrogel, fragrance mix I and II, Amerchol L101 and gentamicin. There were 14 reactions to modern wound care products with highest sensitization rates for hydrocolloids and hydrogels. Patients sensitized to wound care products had significantly more positive patch test reactions.
CONCLUSION
There are sensitisations against modern wound care products, especially hydrogels. That should be considered in patch test of leg ulcer patients.
背景
腿部溃疡患者常发生接触性致敏。现代伤口护理产品宣称具有低过敏可能性。
目的
分析腿部溃疡患者的斑贴试验结果，重点关注现代伤口护理产品。
材料与方法
95例腿部溃疡患者接受了德国标准斑贴试验系列以及常用伤口护理产品的检测。
结果
61%的患者至少有1次阳性反应。最常见的反应见于叔丁基对苯二酚、聚维酮碘、秘鲁香脂、水凝胶、香料混合物I和II、氢化蓖麻油L101和庆大霉素。对现代伤口护理产品有14次反应，其中水胶体和水凝胶的致敏率最高。对伤口护理产品致敏的患者斑贴试验阳性反应明显更多。
结论
存在对现代伤口护理产品的致敏情况，尤其是水凝胶。在腿部溃疡患者的斑贴试验中应予以考虑。
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