Nishimoto Soh, Oyama Tomoki, Matsuda Ken
Department of Plastic Surgery, Kobe Children's Hospital, Kobe, Japan.
Wound Repair Regen. 2007 Jan-Feb;15(1):156-62. doi: 10.1111/j.1524-475X.2006.00196.x.
Platelet-rich plasma (PRP) has attracted attention as a safe and cost-effective source of growth factors that stimulate cells to regenerate tissue. Bone marrow aspirate was processed with the same protocol to obtain PRP from peripheral blood. This concentrate contained condensed nucleated bone marrow cells, which are useful for regenerative medicine, as well as condensed platelets. In PRP derived from bone marrow aspirate, the density of platelets and levels of growth factors (platelet-derived growth factor and transforming growth factor-beta) were the same as in PRP derived from peripheral blood. Condensation of nucleated cells, especially small-sized cells, was confirmed. With a simple and cost-effective technique, source cells and growth factors can be obtained at the same time. This simultaneous concentration of platelets and bone marrow cells has great potential as a source of materials for regenerative medicine.
富血小板血浆（PRP）作为一种安全且经济高效的生长因子来源，能够刺激细胞再生组织，因而受到关注。采用相同方案处理骨髓抽吸物以从外周血中获取PRP。这种浓缩物含有浓缩的有核骨髓细胞，其对再生医学有用，同时还含有浓缩的血小板。在源自骨髓抽吸物的PRP中，血小板密度和生长因子（血小板衍生生长因子和转化生长因子-β）水平与源自外周血的PRP相同。已证实有核细胞，尤其是小型细胞发生了浓缩。通过一种简单且经济高效的技术，可以同时获得源细胞和生长因子。血小板和骨髓细胞的这种同时浓缩作为再生医学的材料来源具有巨大潜力。
