Obermair Franz-Josef, Schröter Aileen, Thallmair Michaela
Brain Research Institute, University of Zurich, and Department of Neuromorphology, ETH Zurich, Zurich, Switzerland.
Physiology (Bethesda). 2008 Oct;23:296-304. doi: 10.1152/physiol.00017.2008.
Growing knowledge about the role of neural progenitor cells supports the hope that stem cell-based therapeutic approaches aimed at restoring function in the lesioned central nervous system can be established. Possible therapies for promoting recovery after spinal cord injury include stimulating the formation of neurons and glial cells by endogenous progenitor cells. This article reviews the current knowledge about the nature of adult progenitor cells in the intact and injured spinal cord and summarizes possibilities and limitations of cellular replacement strategies based on manipulations of endogenous spinal cord progenitor cells and their environment.
对神经祖细胞作用的认识不断深入，让人看到了建立旨在恢复受损中枢神经系统功能的基于干细胞的治疗方法的希望。促进脊髓损伤后恢复的可能疗法包括刺激内源性祖细胞形成神经元和神经胶质细胞。本文综述了目前关于完整和损伤脊髓中成年祖细胞性质的知识，并总结了基于对脊髓内源性祖细胞及其环境进行操作的细胞替代策略的可能性和局限性。
