Hu Zhi-Liang, Reecy James M
Department of Animal Science, Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011-3150, USA.
Mamm Genome. 2007 Jan;18(1):1-4. doi: 10.1007/s00335-006-0105-8. Epub 2007 Jan 23.
Over the past ten years there have been a large number of publications that have described hundreds of quantitative trait loci (QTL) in livestock species. To facilitate the comparison of QTL results across experiments, the Animal QTL database (QTLdb) was developed to house all published QTL information as a public repository. The QTLdb was originally developed to serve the porcine genomics community (previously known as PigQTLdb). We have further developed the QTLdb to house QTL data from multiple species, including but not limited to cattle, chickens, and pigs. In addition, tools have been developed to allow QTL map alignments against consensus linkage maps, radiation hybrid (RH) maps, BAC fingerprinted contig (FPC) maps, single nucleotide polymorphism (SNP) location maps, and human maps. In addition, we have expanded the capabilities of the database such that research tools were developed where "private" preliminary QTL data could be entered and compared against all public data. This allows researchers to visualize data before publication and compare it with published results to aid in data interpretation. To serve this purpose, the database curator/editor tools also include functions that allow registered users to enter their own QTL data, make use of the QTLdb tools for data analysis, and use the QTLdb as a publishing tool (URL: http://www.animalgenome.org).
在过去十年中,有大量出版物描述了家畜物种中的数百个数量性状基因座(QTL)。为便于跨实验比较QTL结果,开发了动物QTL数据库(QTLdb),作为一个公共知识库来存储所有已发表的QTL信息。QTLdb最初是为服务猪基因组学界(以前称为PigQTLdb)而开发的。我们进一步扩展了QTLdb,以存储来自多个物种的QTL数据,包括但不限于牛、鸡和猪。此外,还开发了一些工具,用于将QTL图谱与共识连锁图谱、辐射杂种(RH)图谱、BAC指纹连续群(FPC)图谱、单核苷酸多态性(SNP)定位图谱和人类图谱进行比对。此外,我们还扩展了数据库的功能,开发了研究工具,可输入“私有”的初步QTL数据,并与所有公共数据进行比较。这使研究人员能够在发表前可视化数据,并将其与已发表的结果进行比较,以辅助数据解释。为实现这一目的,数据库管理员/编辑工具还包括一些功能,允许注册用户输入自己的QTL数据,利用QTLdb工具进行数据分析,并将QTLdb用作发布工具(网址:http://www.animalgenome.org)。