Department of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, IA 50011, USA.
Nucleic Acids Res. 2022 Jan 7;50(D1):D956-D961. doi: 10.1093/nar/gkab1116.
The Animal QTLdb (https://www.animalgenome.org/QTLdb) and CorrDB (https://www.animalgenome.org/CorrDB) are unique resources for livestock animal genetics and genomics research which have been used extensively by the international livestock genome research community. This is largely due to the active development of the databases over the years to keep up with the rapid advancement of genome sciences. The ongoing development has ensured that these databases provide researchers not only with continually updated data but also with new web tools to disseminate the data. Through our continued efforts, the databases have evolved from the original Pig QTLdb for cross-experiment QTL data comparisons to an Animal QTLdb hosting 220 401 QTL, SNP association and eQTL data linking phenotype to genotype for 2210 traits. In addition, there are 23 552 correlations for 866 traits and 4273 heritability data on 1069 traits in CorrDB. All these data were curated from 3157 publications that cover seven livestock species. Along with the continued data curation, new species, additional genome builds, and new functions and features have been built into the databases as well. Standardized procedures to support data mapping on multiple species/genome builds and the ability to browse data based on linked ontology terms are highlights of the recent developments.
动物 QTLdb(https://www.animalgenome.org/QTLdb)和 CorrDB(https://www.animalgenome.org/CorrDB)是独特的家畜动物遗传学和基因组学研究资源,被国际家畜基因组研究界广泛使用。这在很大程度上是由于这些数据库多年来的积极发展,以跟上基因组科学的快速发展。正在进行的开发确保了这些数据库不仅为研究人员提供了不断更新的数据,还提供了新的网络工具来传播数据。通过我们的持续努力,这些数据库已经从最初的用于跨实验 QTL 数据比较的 Pig QTLdb 发展成为一个拥有 220401 个 QTL、SNP 关联和 eQTL 数据的 Animal QTLdb,这些数据将表型与基因型联系起来,涵盖了 2210 个性状。此外,CorrDB 中还有 23552 个 866 个性状的相关性和 4273 个 1069 个性状的遗传力数据。所有这些数据都是从涵盖 7 个家畜物种的 3157 篇文献中整理出来的。除了持续的数据整理外,新的物种、额外的基因组构建以及新的功能和特性也被添加到数据库中。支持多个物种/基因组构建的数据映射的标准化程序以及基于链接的本体论术语浏览数据的能力是最近发展的亮点。