Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.
Genetics. 1986 Nov;114(3):943-54. doi: 10.1093/genetics/114.3.943.
A number of previous studies have established that amylase activity can vary between Drosophila strains which are maintained under identical laboratory conditions. In addition, we have recently shown that all strains examined so far are subject to glucose repression of amylase activity. In this study, we show that the degree of glucose repression can vary between strains. Moreover, the glucose repression effect is much more pronounced in larvae than in adult flies. Our results lead to the conclusion that the strain-specific differences in activity and the dietary effects are not independent phenomena. These results have implications for the interpretation of many studies on amylase activity variation, including those experiments which have been designed to link amylase activity variations with fitness differences in nature. A question that naturally arises concerns the molecular basis for these strain-specific variations in the degree of glucose repression of this eukaryotic gene.
已有多项研究证实，在相同的实验室条件下，不同的果蝇品系的淀粉酶活性可能存在差异。此外，我们最近还表明，迄今为止检查的所有菌株都受到葡萄糖对淀粉酶活性的抑制。在这项研究中，我们表明，不同菌株之间的葡萄糖抑制程度可能有所不同。此外，在幼虫中，葡萄糖抑制效应比在成年果蝇中更为明显。我们的研究结果得出的结论是，活性的菌株特异性差异和饮食效应不是独立的现象。这些结果对淀粉酶活性变化的许多研究的解释具有重要意义，包括那些旨在将淀粉酶活性变化与自然界中适应性差异联系起来的实验。自然而然地出现了一个问题，即这种真核基因的葡萄糖抑制程度的菌株特异性变化的分子基础是什么。
