Semenov B F, Vargin V V, Zschiesche W, Veckenstedt A
Intervirology. 1975;5(3-4):220-4. doi: 10.1159/000149899.
The effects of cyclophosphamide and 1,3-(piperidinomethyl)-5-phenyl-5-ethylbarbituric acid on certain flavi- and enterovirus infections in mice were studied. Differential enhancement of mortality rates after extraneural and, less markedly, intracerebral virus inoculation was noted. While depression of humoral and/or cell-mediated immunity is considered to be responsible for the effects observed in flavivirus infections, impaired function of the reticuloendothelial system seems to contribute mainly to the potentiation of Mengo virus infection by the immunodepressants used.
研究了环磷酰胺和1,3-(哌啶甲基)-5-苯基-5-乙基巴比妥酸对小鼠某些黄病毒和肠道病毒感染的影响。在经神经外接种病毒后，死亡率有差异地升高，而经脑内接种病毒后，死亡率升高不太明显。虽然体液免疫和/或细胞介导免疫的抑制被认为是黄病毒感染中观察到的效应的原因，但网状内皮系统功能受损似乎主要是所用免疫抑制剂增强门戈病毒感染的原因。
