基因内重组对有限群体中等位基因数量的影响。
The effect of intragenic recombination on the number of alleles in a finite population.
机构信息
Department of Genetics, University of Alberta, Edmonton, Alberta, Canada T6G 2E9.
出版信息
Genetics. 1978 Apr;88(4):829-44. doi: 10.1093/genetics/88.4.829.
Abstract
A two-site infinite allele model is constructed to study the effect of intragenic recombination on the number of neutral alleles and the distribution of their frequencies in a finite population. The results of theory and Monte Carlo simulation of the two-site model demonstrate that intragenic recombination significantly increases the mean and variance of the number of alleles when the rates of mutation and recombination are as large as the reciprocal of the population size. Data from natural populations indicate that this may be a significant process in generating variation and determining its distribution.
摘要
构建了一个两座位点无限等位基因模型，以研究基因内重组对有限群体中中性等位基因数量及其频率分布的影响。两座位点模型的理论和蒙特卡罗模拟结果表明，当突变和重组率与群体大小的倒数相当时，基因内重组会显著增加等位基因数量的均值和方差。来自自然种群的数据表明，这可能是产生变异和确定其分布的一个重要过程。
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