通过钯催化的碳胺化反应合成官能化吡咯烷的温和条件。
Mild conditions for the synthesis of functionalized pyrrolidines via Pd-catalyzed carboamination reactions.
作者信息
Bertrand Myra Beaudoin, Leathen Matthew L, Wolfe John P
机构信息
Department of Chemistry, University of Michigan, 930 N. University Avenue, Ann Arbor, Michigan 48109-1055, USA.
出版信息
Org Lett. 2007 Feb 1;9(3):457-60. doi: 10.1021/ol062808f.
Abstract
[reaction: see text] The palladium-catalyzed carboamination of N-protected gamma-aminoalkenes with aryl bromides and triflates has been achieved under new, mild reaction conditions using the weak base Cs(2)CO(3) in dioxane solvent. These reactions tolerate a wide variety of functional groups, including enolizable ketones, nitro groups, methyl esters, and acetates, which are not compatible with previously described conditions.
摘要
[反应：见正文] 在新的温和反应条件下，使用弱碱碳酸铯（Cs₂CO₃）在二氧六环溶剂中，实现了钯催化的N-保护的γ-氨基烯烃与芳基溴化物和三氟甲磺酸酯的碳胺化反应。这些反应能耐受多种官能团，包括可烯醇化的酮、硝基、甲酯和乙酸酯，而这些官能团与先前描述的条件不相容。
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