来自极端微生物的蛋白质作为具有高度社会意义的先进生物技术应用的稳定工具。
Proteins from extremophiles as stable tools for advanced biotechnological applications of high social interest.
作者信息
de Champdoré Marcella, Staiano Maria, Rossi Mosè, D'Auria Sabato
机构信息
Institute of Protein Biochemistry, CNR, Italian National Research Council, Via Pietro Castellino, 111, 80131 Naples, Italy.
出版信息
J R Soc Interface. 2007 Apr 22;4(13):183-91. doi: 10.1098/rsif.2006.0174.
Extremophiles are micro-organisms adapted to survive in ecological niches defined as 'extreme' for humans and characterized by the presence of adverse environmental conditions, such as high or low temperatures, extreme values of pH, high salt concentrations or high pressure. Biomolecules isolated from extremophiles possess extraordinary properties and, in particular, proteins isolated from extremophiles represent unique biomolecules that function under severe conditions, comparable to those prevailing in various industrial processes. In this article, we will review some examples of recent applications of thermophilic proteins for the development of a new class of fluorescence non-consuming substrate biosensors for monitoring the levels of two analytes of high social interest, such as glucose and sodium.
极端微生物是一类适应在对人类而言被定义为“极端”的生态位中生存的微生物，其特征是存在不利的环境条件，如高温或低温、极端的pH值、高盐浓度或高压。从极端微生物中分离出的生物分子具有非凡的特性，特别是从极端微生物中分离出的蛋白质代表了在严苛条件下起作用的独特生物分子，这些条件与各种工业过程中普遍存在的条件相当。在本文中，我们将回顾嗜热蛋白质在开发新型荧光非消耗性底物生物传感器方面的一些最新应用实例，这些生物传感器用于监测两种具有高度社会关注度的分析物的水平，如葡萄糖和钠。
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