• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia.

作者信息

Marinelli A, Bossi D, Pelicci P G, Minucci S

机构信息

Department of Biomolecular Sciences and Biotechnology, University of Milan, Milan, Italy.

出版信息

Leukemia. 2007 Apr;21(4):647-50. doi: 10.1038/sj.leu.2404572. Epub 2007 Jan 25.

DOI:10.1038/sj.leu.2404572
PMID:17252005
Abstract

Alterations of the retinoic acid receptor (RAR)alpha locus are found in 100% of acute promyelocytic leukemia patients, where chromosomal translocations generate the promyelocytic leukemia (PML)-RARalpha chimeric protein. Here, we have investigated the biological properties of the other RAR isoforms (RARbeta and RARgamma), through the generation and characterization of artificial PML-RAR'x' fusion proteins. Surprisingly, we found that all of the RAR isoforms share an identical oncogenic potential in vitro, thus implying that the selection of the RARalpha locus in leukemia patients must occur--rather than through functional differences among the various RAR isoforms-as the consequence of the nuclear architecture of the different RAR loci.

摘要

相似文献

1
A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia.
Leukemia. 2007 Apr;21(4):647-50. doi: 10.1038/sj.leu.2404572. Epub 2007 Jan 25.
2
The t(15;17) translocation in acute promyelocytic leukemia.急性早幼粒细胞白血病中的t(15;17)易位
Leukemia. 1994 Oct;8(10):1615-21.
3
Pulsed-field gel electrophoresis analysis of retinoic acid receptor-alpha and promyelocytic leukemia rearrangements. Detection of the t(15;17) translocation in the diagnosis of acute promyelocytic leukemia.维甲酸受体-α和早幼粒细胞白血病重排的脉冲场凝胶电泳分析。急性早幼粒细胞白血病诊断中t(15;17)易位的检测。
Am J Pathol. 1993 Nov;143(5):1301-11.
4
Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha.在表达PML/RARα、PLZF/RARα或NPM/RARα的转基因小鼠中具有不同表型的白血病。
Oncogene. 2006 Mar 23;25(13):1974-9. doi: 10.1038/sj.onc.1209216.
5
The PML-RAR alpha gene product of the t(15;17) translocation inhibits retinoic acid-induced granulocytic differentiation and mediated transactivation in human myeloid cells.t(15;17)易位产生的PML-RARα基因产物可抑制人髓系细胞中视黄酸诱导的粒细胞分化并介导反式激活。
Oncogene. 1994 Feb;9(2):545-51.
6
The self-association coiled-coil domain of PML is sufficient for the oncogenic conversion of the retinoic acid receptor (RAR) alpha.PML 自身缔合卷曲螺旋结构域足以使维甲酸受体 (RAR) α发生致癌转化。
Leukemia. 2011 May;25(5):814-20. doi: 10.1038/leu.2011.18. Epub 2011 Feb 18.
7
Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML.非重排等位基因RARα或PML表达增加的急性早幼粒细胞白血病细胞的生长抑制
Oncogene. 1995 Jun 15;10(12):2307-14.
8
In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia.异常组蛋白去乙酰化酶募集和维甲酸受体α阻断在急性早幼粒细胞白血病发病机制中的作用的体内分析
J Exp Med. 2006 Apr 17;203(4):821-8. doi: 10.1084/jem.20050616. Epub 2006 Mar 20.
9
Characterization of the PML-RAR alpha chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation.急性早幼粒细胞白血病特异性t(15;17)易位产生的PML-RARα嵌合产物的特征分析
Cancer Res. 1992 Jul 1;52(13):3687-92.
10
Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy.急性早幼粒细胞白血病中的变异型PML-RAR（α）融合转录本：利用RAR（α）基因内含子2的隐蔽编码序列并鉴定出一种对维甲酸治疗耐药的新临床亚型。
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7640-5. doi: 10.1073/pnas.112194799.

引用本文的文献

1
Molecular Heterogeneity of Pediatric AML with Atypical Promyelocytes Accumulation in Children-A Single Center Experience.儿童伴非典型早幼粒细胞蓄积的 AML 的分子异质性：单中心经验。
Genes (Basel). 2023 Mar 8;14(3):675. doi: 10.3390/genes14030675.
2
Case report: Identification of a novel HNRNPC::RARG fusion in acute promyelocytic leukemia lacking RARA rearrangement.病例报告：在缺乏RARA重排的急性早幼粒细胞白血病中鉴定出一种新型HNRNPC::RARG融合基因。
Front Oncol. 2023 Jan 9;12:1028651. doi: 10.3389/fonc.2022.1028651. eCollection 2022.
3
Case report: A rare case of acute myeloid leukemia with CPSF6-RARG fusion resembling acute promyelocytic leukemia.
病例报告：一例罕见的急性髓系白血病，伴有CPSF6-RARG融合基因，类似急性早幼粒细胞白血病。
Front Oncol. 2022 Sep 15;12:1011023. doi: 10.3389/fonc.2022.1011023. eCollection 2022.
4
Acute Promyelocytic Leukemia: A History over 60 Years-From the Most Malignant to the most Curable Form of Acute Leukemia.急性早幼粒细胞白血病：60 多年的历程——从最恶性的急性白血病形式到最可治愈的形式
Oncol Ther. 2019 Jun;7(1):33-65. doi: 10.1007/s40487-018-0091-5. Epub 2019 Feb 5.
5
Classic and Variants APLs, as Viewed from a Therapy Response.从治疗反应角度看经典型和变异型急性早幼粒细胞白血病
Cancers (Basel). 2020 Apr 14;12(4):967. doi: 10.3390/cancers12040967.
6
Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D.通过 DNAM-1 和 NKG2D 增强自然杀伤细胞介导的肉瘤靶向作用。
Front Immunol. 2020 Jan 28;11:40. doi: 10.3389/fimmu.2020.00040. eCollection 2020.
7
RARG Gene Dysregulation in Acute Myeloid Leukemia.急性髓系白血病中的视黄酸受体γ基因失调
Front Mol Biosci. 2019 Oct 24;6:114. doi: 10.3389/fmolb.2019.00114. eCollection 2019.
8
A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel - fusion.具有早幼粒细胞特征的急性髓系白血病病例，其特征为表达一种新型融合基因。
Blood Adv. 2018 Jun 12;2(11):1295-1299. doi: 10.1182/bloodadvances.2017014183.
9
Identification of a novel PML-RARG fusion in acute promyelocytic leukemia.急性早幼粒细胞白血病中一种新型PML-RARG融合基因的鉴定
Leukemia. 2017 Sep;31(9):1992-1995. doi: 10.1038/leu.2017.167. Epub 2017 May 30.
10
Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia.维甲酸/类视黄醇信号在介导 NUP98-RARG 白血病的转化和治疗反应中的关键作用。
Leukemia. 2015 May;29(5):1153-62. doi: 10.1038/leu.2014.334. Epub 2014 Dec 16.