[输血和肾移植患者中的丙型肝炎病毒抗体]
[Hepatitis C virus antibodies in patients following blood transfusion and kidney transplantation].
作者信息
Baur P, Daniel V, Pomer S, Scheurlen H, Opelz G, Roelcke D
机构信息
Institut für Immunologie und Serologie, Universität Heidelberg.
出版信息
Beitr Infusionsther. 1991;28:27-8.
The prevalence of anti-HCV in patients after kidney transplantation was tested by HCV-Antibody-ELISA (Ortho Diagnostics). In addition, reactive samples were tested by HCV-EIA (Abbott Laboratories), neutralization, anti-HBc (Corzyme, Abbott) and by HBs-Ag (Auszyme, Abbott). 27 of 271 patients (10%) were anti-HCV positive. Receiving more than one kidney graft (TPL) or the transfusion of more than four blood units (BU) increases the risk of HCV infection four times (OR: 4.1; p less than 0.01) or 2.5 times (OR: 2.5; p less than 0.05), respectively, compared with one TPL or less than 4 BU. Receiving more than one kidney graft and transfusion of more than four BU raises the risk of HCV infection 6.8 times. 52% of anti-HCV positive patients were anti-HBc positive, 48% were anti-HBc negative as well as HBs-Ag negative.
采用丙型肝炎病毒抗体酶联免疫吸附测定法（奥索诊断公司产品）检测肾移植术后患者的抗丙型肝炎病毒（抗-HCV）流行情况。此外，对反应性样本采用丙型肝炎病毒酶免疫测定法（雅培实验室产品）、中和试验、抗乙型肝炎核心抗体检测（科齐姆，雅培）以及乙型肝炎表面抗原检测（奥兹姆，雅培）进行检测。271例患者中有27例（10%）抗-HCV呈阳性。与接受一个以下肾移植或输注4个以下血单位相比，接受一个以上肾移植（TPL）或输注4个以上血单位（BU）会使丙型肝炎病毒感染风险分别增加4倍（比值比：4.1；p<0.01）或2.5倍（比值比：2.5；p<0.05）。接受一个以上肾移植且输注4个以上血单位会使丙型肝炎病毒感染风险增加6.8倍。52%的抗-HCV阳性患者抗-HBc呈阳性，48%的患者抗-HBc呈阴性且HBs-Ag呈阴性。
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