短小诺卡氏菌TP-A0861产生的黏铁素A的绝对构型及抗肿瘤活性
Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861.
作者信息
Miyanaga Satoshi, Obata Takamasa, Onaka Hiroyasu, Fujita Tsuyoshi, Saito Noriko, Sakurai Hiroaki, Saiki Ikuo, Furumai Tamotsu, Igarashi Yasuhiro
机构信息
Department of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.
出版信息
J Antibiot (Tokyo). 2006 Nov;59(11):698-703. doi: 10.1038/ja.2006.93.
In the screening of antitumor compounds from microbial secondary metabolites, myxochelin A was isolated from a culture broth of Nonomuraea pusilla TP-A0861. The absolute configuration was determined to be S by synthesizing both enantiomers from an L- or D-lysine derivative and comparing their specific rotations. Both enantiomers of myxochelin A showed remarkable inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells at non-cytotoxic concentrations.
在从微生物次级代谢产物中筛选抗肿瘤化合物的过程中，从微小诺卡氏菌TP-A0861的培养液中分离出了黏铁载体A。通过从L-或D-赖氨酸衍生物合成两种对映体并比较它们的比旋光度，确定其绝对构型为S。在无细胞毒性浓度下，黏铁载体A的两种对映体对小鼠结肠26-L5癌细胞的侵袭均显示出显著的抑制作用。
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