Cho Ji Young, Williams Philip G, Kwon Hak Chol, Jensen Paul R, Fenical William
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA.
J Nat Prod. 2007 Aug;70(8):1321-8. doi: 10.1021/np070101b. Epub 2007 Jul 14.
Four new 3-methyl-4-ethylideneproline-containing peptides, lucentamycins A-D (1-4), have been isolated from the fermentation broth of a marine-derived actinomycete identified by phylogenetic methods as Nocardiopsis lucentensis (strain CNR-712). The planar structures of the new compounds were assigned on the basis of 1D and 2D NMR spectroscopic techniques, while the absolute configurations of the amino acid residues were determined by application of the advanced Marfey method. Lucentamycins A (1) and B (2) showed significant in vitro cytotoxicity against HCT-116 human colon carcinoma.
从一株通过系统发育方法鉴定为透明诺卡氏菌（菌株CNR-712）的海洋放线菌发酵液中分离出了四种新的含3-甲基-4-亚乙基脯氨酸的肽，即透明霉素A-D（1-4）。基于一维和二维核磁共振光谱技术确定了新化合物的平面结构，同时通过先进的马尔菲方法确定了氨基酸残基的绝对构型。透明霉素A（1）和B（2）对HCT-116人结肠癌显示出显著的体外细胞毒性。
