从滇桑（Morus yunanensis Koidz.）茎皮中分离得到一种新型狄尔斯-阿尔德（Diels-Alder）型加合物和两种新黄酮。

A new Diels-Alder type adduct and two new flavones from the stem bark of Morus yunanensis Koidz.

作者信息

Cui Xi-Qiang, Wang Lei, Yan Ren-Yi, Tan Yong-Xia, Chen Ruo-Yun, Yu De-Quan

机构信息

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education and Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

J Asian Nat Prod Res. 2008 Mar-Apr;10(3-4):361-6. doi: 10.1080/10286020701833537.

DOI:10.1080/10286020701833537

PMID:18348061

Abstract

Fractionation of the ethanolic extract of the stem bark of Morus yunanensis resulted in the isolation of a new Diels-Alder type adduct and two new flavones, named yunanensin A (1), yunanensol A (2) and yunanensol B (3), respectively, together with a known flavone (4). Their structures were determined on the basis of spectroscopic analysis and chemical methods. Among them, compound 1 showed moderate antioxidant and significant cytotoxic activities, and compound 2 showed potent anti-inflammatory activity.

摘要

对滇桑茎皮乙醇提取物进行分离，得到一个新的狄尔斯-阿尔德型加合物和两个新的黄酮类化合物，分别命名为滇桑素A（1）、滇桑醇A（2）和滇桑醇B（3），以及一个已知的黄酮类化合物（4）。通过光谱分析和化学方法确定了它们的结构。其中，化合物1表现出中等抗氧化活性和显著的细胞毒性活性，化合物2表现出较强的抗炎活性。