Ueta Mayumi, Sotozono Chie, Tokunaga Katsushi, Yabe Toshio, Kinoshita Shigeru
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi, Kyoto, Japan.
Am J Ophthalmol. 2007 Feb;143(2):367-8. doi: 10.1016/j.ajo.2006.09.029. Epub 2006 Oct 25.
To investigate the association between HLA class I antigens and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with ocular complications in Japanese.
Case-control study.
We examined the histocompatibility antigen genes HLA-A, -B, and -C of 40 Japanese SJS/TEN patients with ocular complications and 113 healthy Japanese volunteers by polymerase chain reaction amplification and subsequent hybridization with sequence-specific oligonucleotide probes (PCR-SSO).
We clarified that HLA-A*0206 is strongly associated with SJS/TEN with ocular complications in the Japanese.
Because this finding is completely different from data reported elsewhere on Taiwanese Han Chinese patients and Caucasian patients, it suggests strong ethnic differences in the HLA-SJS association and points to the need for studies in other ethnic populations in order to obtain a global picture.
研究日本人群中HLA I类抗原与伴有眼部并发症的史蒂文斯-约翰逊综合征（SJS）/中毒性表皮坏死松解症（TEN）之间的关联。
病例对照研究。
我们通过聚合酶链反应扩增以及随后与序列特异性寡核苷酸探针杂交（PCR-SSO），检测了40例伴有眼部并发症的日本SJS/TEN患者和113名健康日本志愿者的组织相容性抗原基因HLA-A、-B和-C。
我们明确了HLA-A*0206与日本伴有眼部并发症的SJS/TEN密切相关。
由于这一发现与其他地方报道的台湾汉族患者和白种人患者的数据完全不同，这表明HLA与SJS的关联存在强烈的种族差异，并指出有必要在其他种族人群中开展研究以获得全面的认识。
