成年和胎儿小鼠体内内源性致癌RNA病毒基因表达：主要病毒糖蛋白gp70的定量、组织学及生理学研究
Endogenous oncornaviral gene expression in adult and fetal mice: quantitative, histologic, and physiologic studies of the major viral glycorprotein, gp70.
作者信息
Lerner R A, Wilson C B, Villano B C, McConahey P J, Dixon F J
出版信息
J Exp Med. 1976 Jan 1;143(1):151-66. doi: 10.1084/jem.143.1.151.
Abstract
Endogenous expression of the murine leukemia virus (MuLV) genome has been studied in a number of strains of mice. Expression of the major envelope glycoprotein, gp70, is restricted to certain anatomical sites and cell types, prominent among which are lymphoid and epithelial cells. On a quantitative basis, the major site of gp70 expression is the male genital tract. During development, gp70 first appears in the hematopoietic liver of 14-day-old embryos and by day 18, it is already expressed at anatomical sites similar to those of the adult. In toto, these results show that control of expression of the MuLV genome in adult and developing mice is linked to differentiation.
摘要
已在多种小鼠品系中研究了鼠白血病病毒（MuLV）基因组的内源性表达。主要包膜糖蛋白gp70的表达局限于某些解剖部位和细胞类型，其中突出的是淋巴样细胞和上皮细胞。从数量上看，gp70表达的主要部位是雄性生殖道。在发育过程中，gp70首先出现在14日龄胚胎的造血肝脏中，到18日龄时，它已在与成年小鼠相似的解剖部位表达。总体而言，这些结果表明，成年小鼠和发育中小鼠中MuLV基因组表达的控制与分化有关。
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本文引用的文献
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2
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J Exp Med. 1971 Jun 1;133(6):1334-55. doi: 10.1084/jem.133.6.1334.
3
Oncogenes of RNA tumor viruses as determinants of cancer.作为癌症决定因素的RNA肿瘤病毒癌基因。
Proc Natl Acad Sci U S A. 1969 Nov;64(3):1087-94. doi: 10.1073/pnas.64.3.1087.
4
Virus particles and viral antigens in chicken tissues free of infectious avian leukosis virus.不含传染性禽白血病病毒的鸡组织中的病毒粒子和病毒抗原。
Proc Natl Acad Sci U S A. 1967 Sep;58(3):808-17. doi: 10.1073/pnas.58.3.808.
5
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Lab Invest. 1973 Sep;29(3):278-81.
6
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7
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8
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9
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